Plant Name: Vincetoxicum pycnostelma
Taxonomic Information:
Plant ID: NPO24694
Plant Latin Name: Vincetoxicum pycnostelma
Taxonomy Genus: Vincetoxicum
Taxonomy Family: Apocynaceae
Plant External Links:
NCBI TaxonomyDB:
228726
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TDP1; | |
| MAPK1; | |
| PPARA; | |
| TLR2; | |
| TP53; | |
| HTT; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0007610; behavior | GO:0007610; behavior | 8.756E-07 | 1.467E-02 | HTT, MAPK1, PPARA, TLR2, TP53 |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 2.119E-06 | 1.467E-02 | LMNA, PPARA, TLR2, TP53 |
| MF | GO:0005488; binding | GO:0097371; MDM2/MDM4 family protein binding | 3.149E-06 | 1.467E-02 | PPARA, TP53 |
| MF | GO:0005488; binding | GO:0019902; phosphatase binding | 3.262E-05 | 1.015E-01 | MAPK1, PPARA, TP53 |
| BP | GO:0051179; localization | GO:1903827; regulation of cellular protein localization | 6.151E-05 | 1.230E-01 | LMNA, MAPK1, TLR2, TP53 |
| BP | GO:0051179; localization | GO:0090316; positive regulation of intracellular protein transport | 6.623E-05 | 1.230E-01 | MAPK1, TLR2, TP53 |
| BP | GO:0050896; response to stimulus | GO:0031663; lipopolysaccharide-mediated signaling pathway | 6.938E-05 | 1.230E-01 | MAPK1, TLR2 |
| BP | GO:0009987; cellular process | GO:0006915; apoptotic process | 7.111E-05 | 1.230E-01 | HTT, MAPK1, TLR2, TP53 |
| BP | GO:0008152; metabolic process | GO:1902893; regulation of pri-miRNA transcription from RNA polymerase II promoter | 7.874E-05 | 1.230E-01 | PPARA, TP53 |
| MF | GO:0005488; binding | GO:0001221; transcription cofactor binding | 9.924E-05 | 1.271E-01 | PPARA, TP53 |
| CC | GO:0044464; cell part | GO:0005770; late endosome | 1.321E-03 | 2.538E-01 | HTT, MAPK1 |
| CC | GO:0044464; cell part | GO:0005737; cytoplasm | 1.848E-03 | 2.714E-01 | CYP3A4, HTT, MAPK1, TDP1, TLR2, TP53 |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 3.436E-03 | 3.310E-01 | HTT, LMNA, MAPK1, PPARA, TP53 |
| CC | Unclassified; | GO:0106003; amyloid-beta complex | 4.548E-03 | 3.588E-01 | TLR2 |
| CC | GO:0044464; cell part | GO:0030424; axon | 4.683E-03 | 3.642E-01 | HTT, MAPK1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.832E-05 | 8.449E-04 | LMNA, MAPK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 2.078E-05 | 8.449E-04 | MAPK1, TP53, TLR2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 1.571E-05 | 8.449E-04 | MAPK1, PPARA, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 5.557E-05 | 1.379E-03 | MAPK1, TP53, TLR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 5.654E-05 | 1.379E-03 | MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 2.582E-04 | 2.766E-03 | MAPK1, TP53, TLR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 2.133E-04 | 2.766E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 1.139E-04 | 2.316E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05213 | Endometrial cancer | 1.838E-04 | 2.766E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 2.876E-04 | 2.766E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 2.616E-04 | 2.766E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 2.965E-04 | 2.766E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 3.431E-04 | 2.766E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 3.056E-04 | 2.766E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 3.627E-04 | 2.766E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 5.388E-04 | 3.867E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 3.627E-04 | 2.766E-03 | MAPK1, TLR2 |
| 09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 7.631E-04 | 4.900E-03 | MAPK1, TLR2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05142 | Chagas disease (American trypanosomiasis) | 7.347E-04 | 4.900E-03 | MAPK1, TLR2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 9.443E-04 | 5.179E-03 | MAPK1, TLR2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 9.443E-04 | 5.179E-03 | MAPK1, TP53 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 9.763E-04 | 5.179E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 1.251E-03 | 6.360E-03 | TP53, TLR2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 9.763E-04 | 5.179E-03 | MAPK1, TP53 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
