Plant Name: Toxicodendron succedaneum
Taxonomic Information:
Plant ID: NPO24652
Plant Latin Name: Toxicodendron succedaneum
Taxonomy Genus: Toxicodendron
Taxonomy Family: Anacardiaceae
Plant External Links:
NCBI TaxonomyDB:
269721
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
China; IndiaTraditional Medicine System:
Sowa-Rigpa; TCM; Unani; Ayurveda; SiddhaGeographical Distribution:
India; China
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| OPRD1; NPSR1; | |
| RECQL; TDP1; GLO1; ALOX12; HSD17B10; NOX4; APEX1; POLB; | |
| ACHE; | |
| CDC25B; | |
| TOP2A; | |
| CDK6; MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB; | |
| RORC; | |
| NR1H4; | |
| CAPN1; | |
| HIF1A; TP53; | |
| SLC2A1; | |
| HTT; RAB9A; LMNA; NPC1; XBP1; HSP90AA1; | |
| L3MBTL1; SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CAPN1 | Calpain 1 | P07384 | CHEMBL3891 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
| Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
| Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Protein Kinase | CDK6 | Cyclin-dependent kinase 6 | Q00534 | CHEMBL2508 |
| Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| SLC superfamily of solute carriers | SLC2A1 | Glucose transporter | P11166 | CHEMBL2535 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | XBP1 | X-box-binding protein 1 | P17861 | CHEMBL1741176 |
| Unclassified | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | CHEMBL3880 |
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 2.384E-07 | 1.445E-04 | APEX1, AURKB, CDC25B, CDK1, CDK6, HIF1A, HSP90AA1, HTT, L3MBTL1, LMNA, NR1H4, PIM1, POLB, RECQL, RORC, SMN1, SMN2, TOP2A, TP53, XBP1 |
| BP | GO:0008283; cell proliferation | GO:0008284; positive regulation of cell proliferation | 9.244E-07 | 3.871E-04 | ALOX12, CAPN1, CDC25B, CDK1, CDK6, FLT3, HIF1A, IGF1R, KDR, PIM1, XBP1 |
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 1.756E-06 | 5.976E-04 | ACHE, FLT3, HSP90AA1, HTT, IGF1R, KDR, L3MBTL1, MET, RAB9A, SLC2A1, SMN1, SMN2, TOP2A, TP53 |
| BP | GO:0008152; metabolic process | GO:0018108; peptidyl-tyrosine phosphorylation | 1.842E-06 | 6.172E-04 | AXL, FLT3, HSP90AA1, IGF1R, KDR, MET |
| BP | GO:0040011; locomotion | GO:0030335; positive regulation of cell migration | 2.329E-06 | 7.296E-04 | ALOX12, HIF1A, IGF1R, KDR, MET, NOX4, TP53, XBP1 |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 3.571E-06 | 1.010E-03 | AURKB, AXL, CDK1, CDK6, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, RECQL, TOP2A, TP53 |
| BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 3.972E-06 | 1.055E-03 | APEX1, POLB |
| BP | GO:0008152; metabolic process | GO:0032787; monocarboxylic acid metabolic process | 4.221E-06 | 1.094E-03 | ALOX12, CYP1A1, CYP1B1, GLO1, HIF1A, NPC1, NR1H4, XBP1 |
| MF | GO:0005488; binding | GO:0043621; protein self-association | 4.172E-06 | 1.094E-03 | ACHE, FLT3, SLC2A1, TP53 |
| BP | GO:0009987; cellular process | GO:0071407; cellular response to organic cyclic compound | 5.747E-06 | 1.303E-03 | APEX1, CYP1A1, CYP1B1, FLT3, NOX4, NPC1, RORC |
| BP | GO:0009987; cellular process | GO:0071396; cellular response to lipid | 6.304E-06 | 1.401E-03 | AXL, CDK6, FLT3, NPC1, NR1H4, RORC, XBP1 |
| BP | GO:0009987; cellular process | GO:0070301; cellular response to hydrogen peroxide | 6.815E-06 | 1.469E-03 | APEX1, AXL, CDK1, CYP1B1 |
| BP | GO:0050896; response to stimulus | GO:0055093; response to hyperoxia | 9.869E-06 | 2.027E-03 | CYP1A1, POLB, TP53 |
| BP | GO:0032502; developmental process | GO:0045766; positive regulation of angiogenesis | 1.396E-05 | 2.577E-03 | ALOX12, CYP1B1, HIF1A, KDR, XBP1 |
| MF | GO:0005488; binding | GO:0008134; transcription factor binding | 1.926E-05 | 3.225E-03 | APEX1, FLT3, HIF1A, HTT, NR1H4, PIM1, TP53, XBP1 |
| BP | GO:0008152; metabolic process | GO:2000377; regulation of reactive oxygen species metabolic process | 2.187E-05 | 3.527E-03 | CYP1B1, HIF1A, HSP90AA1, NOX4, TP53 |
| MF | GO:0003824; catalytic activity | GO:0003824; catalytic activity | 2.814E-05 | 4.226E-03 | ACHE, ALOX12, APEX1, AURKB, AXL, CAPN1, CDC25B, CDK1, CDK6, CYP1A1, CYP1B1, FLT3, GLO1, HSD17B10, HSP90AA1, IGF1R, KDR, MET, NOX4, PIM1, POLB, RAB9A, RECQL, TDP1, TOP2A |
| MF | GO:0005488; binding | GO:0019900; kinase binding | 4.287E-05 | 6.022E-03 | AURKB, CDC25B, HIF1A, HSP90AA1, HTT, SLC2A1, TOP2A, TP53 |
| BP | GO:0008152; metabolic process | GO:0046777; protein autophosphorylation | 4.447E-05 | 6.207E-03 | AURKB, FLT3, IGF1R, KDR, PIM1 |
| BP | GO:0050896; response to stimulus | GO:0042149; cellular response to glucose starvation | 5.638E-05 | 7.227E-03 | SLC2A1, TP53, XBP1 |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 5.642E-05 | 7.227E-03 | HIF1A, LMNA, OPRD1, TP53 |
| MF | GO:0005488; binding | GO:0031072; heat shock protein binding | 5.857E-05 | 7.415E-03 | CDK1, HIF1A, HTT, KDR |
| MF | GO:0005488; binding | GO:0042826; histone deacetylase binding | 6.538E-05 | 8.001E-03 | HIF1A, HSP90AA1, TOP2A, TP53 |
| MF | GO:0060089; molecular transducer activity | GO:0005021; vascular endothelial growth factor-activated receptor activity | 8.289E-05 | 9.809E-03 | FLT3, KDR |
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.911E-07 | 1.872E-05 | FLT3, SLC2A1, TP53, MET, HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 8.066E-07 | 3.952E-05 | HSP90AA1, CDK6, FLT3, SLC2A1, HIF1A, MET, TP53, IGF1R |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 1.092E-05 | 3.566E-04 | CDK6, TP53, MET, IGF1R |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 2.203E-05 | 5.396E-04 | CDK6, PIM1, CYP1B1, TP53, MET, CDC25B |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 4.771E-05 | 6.679E-04 | HSP90AA1, CDK6, KDR, TP53, MET, IGF1R |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 4.459E-05 | 6.679E-04 | KDR, TP53, HIF1A, MET, IGF1R |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04914 | Progesterone-mediated oocyte maturation | 3.908E-05 | 6.679E-04 | HSP90AA1, CDK1, CDC25B, IGF1R |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 1.261E-04 | 1.373E-03 | CYP1A1, CYP1B1, IGF1R |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 2.754E-04 | 2.567E-03 | CDK6, TP53, IGF1R |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04110 | Cell cycle | 9.788E-05 | 1.199E-03 | CDK6, CDK1, TP53, CDC25B |
| 09160 Human Diseases | 09161 Cancers | hsa05211 | Renal cell carcinoma | 2.881E-04 | 2.567E-03 | SLC2A1, MET, HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 6.657E-04 | 4.529E-03 | POLB, CDK6, CDK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 4.081E-04 | 3.076E-03 | FLT3, TP53, MET, IGF1R |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 6.933E-04 | 4.529E-03 | HSP90AA1, TP53, IGF1R |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04115 | p53 signaling pathway | 3.286E-04 | 2.683E-03 | CDK6, CDK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 1.561E-03 | 8.532E-03 | POLB, XBP1, SLC2A1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 1.060E-03 | 6.489E-03 | SLC2A1, HIF1A, IGF1R |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.567E-03 | 8.532E-03 | SLC2A1, TP53, HIF1A |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.883E-03 | 9.712E-03 | POLB, APEX1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Overactive bladder disorder | C67, N32.81 | OPRD1; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | KDR; HSP90AA1; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; |
| C00-D49: Neoplasms | AML | NA | KDR; FLT3; |
| C00-D49: Neoplasms | Colon cancer | C50 | FLT3; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | MET; |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A; |
| C00-D49: Neoplasms | Leukemia | C90-C95 | FLT3; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| NA: NA | Anaplastic mixed oligoastrocytoma | NA | FLT3; |
| I00-I99: Diseases of the circulatory system | Ischemic heart diseases | I20-I25 | OPRD1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | IGF1R; |
| K00-K95: Diseases of the digestive system | Liver disease | K70-K77 | MET; |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE; OPRD1; |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR; |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | MET; IGF1R; KDR; |
| NA: NA | Hematopoietic stem cell transplantation | NA | FLT3; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | AURKB; TP53; HSP90AA1; |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MET; IGF1R; KDR; AXL; |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | KDR; |
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; |
| C00-D49: Neoplasms | Malignant adrenal gland cancer | C74.0 | IGF1R; |
| I00-I99: Diseases of the circulatory system | Heart disease | I00-I52 | MET; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR; |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR; |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE; |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | IGF1R; HSP90AA1; |
| NA: NA | Acute nonspecific diarrhea | NA | OPRD1; |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | FLT3; |
| G00-G99: Diseases of the nervous system G00-G99 | Acute migraine | G43 | OPRD1; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | AURKB; FLT3; TP53; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Growth failure | R62.8 | IGF1R; |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR; |
| C00-D49: Neoplasms | Metastasis | C00-C97 | AXL; |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ACHE; |
| C00-D49: Neoplasms | Glioblastoma | NA | FLT3; |
| C00-D49: Neoplasms | Glioma | C71 | KDR; |
| C00-D49: Neoplasms | Gliosarcoma | NA | FLT3; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE; |
| C00-D49: Neoplasms | Metastatic HER2-negative gastric cancer | NA | MET; |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR; |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; |
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | OPRD1; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cough | R05 | OPRD1; |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A; |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR; |
| N00-N99: Diseases of the genitourinary system | Bladder disease | N30-N32 | OPRD1; |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE; |
| N00-N99: Diseases of the genitourinary system | Urinary incontinence | N39.3, N39.4, R32 | OPRD1; |
| NA: NA | Upper abdominal bloating | NA | ACHE; |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | KDR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | FLT3; |
| C00-D49: Neoplasms | Prostate cancer | C61 | FLT3; |
| C00-D49: Neoplasms | Melanoma | C43 | KDR; HSP90AA1; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | KDR; |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3; |
| NA: NA | Chronic diarrhea associated with inflammatory bowel disease | NA | OPRD1; |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriatic disorder | L40 | IGF1R; |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A; |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | KDR; |
| C00-D49: Neoplasms | Myeloid leukemia | C92 | FLT3; |
| K00-K95: Diseases of the digestive system | Chemotherapy-induced mucositis | K12.3 | MET; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | KDR; TP53; |
| NA: NA | GIST | NA | FLT3; |
| C00-D49: Neoplasms | Refractory hematological malignancies | NA | HSP90AA1; |
| C00-D49: Neoplasms | CLL | NA | FLT3; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE; |
| C00-D49: Neoplasms | Ocular cancer | C69 | APEX1; |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | ACHE; |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | KDR; |
| C00-D49: Neoplasms | Renal cancer | C64 | KDR; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| C00-D49: Neoplasms | Myelofibrosis | C94.4, D47.4 | FLT3; |
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE; |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | MET; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | OPRD1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Premature ejaculation | F52.4 | OPRD1; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | OPRD1; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Moderate-to-severe pain | R52, G89 | OPRD1; |
| C00-D49: Neoplasms | Breast cancer | C50 | CDK1; IGF1R; KDR; FLT3; HSP90AA1; |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR; |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2; |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | NPSR1; |
| G00-G99: Diseases of the nervous system G00-G99 | Motor neurone disease | G12.2 | IGF1R; |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | PIM1; MET; CDK1; IGF1R; KDR; FLT3; ACHE; HIF1A; TP53; CDC25B; HSP90AA1; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | IGF1R; KDR; FLT3; TP53; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | KDR; FLT3; |
| H00-H59: Diseases of the eye and adnexa | Graves' ophthalmopathy | H06.2 | IGF1R; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TOP2A; MET; AURKB; IGF1R; KDR; FLT3; HIF1A; TP53; |
| J00-J99: Diseases of the respiratory system | Airway inflammation | J00-J99 | FLT3; |
| K00-K95: Diseases of the digestive system | Diarrhea-predominant IBS | K58.0 | OPRD1; |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | CDK1; IGF1R; ACHE; OPRD1; |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE; |
| C00-D49: Neoplasms | Liver cancer | C22 | IGF1R; KDR; |
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
