CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR4; FFAR1;
Hydrolase	GAA;
Lyase	CA2; CA12; CA9; CA14;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Enzyme_unclassified	ALOX15; USP2; BRCA1; POLB;
Cysteine protease	CASP1; CASP7;
Transcription Factor	AHR; TP53;
Plant homeodomain	KMT2A;
Unclassified	HTT; NPC1; RAB9A; LMNA; FABP3; FABP5; FABP4; HBB;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP1B1; CYP1A1; CYP2D6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990

Showing 1 to 10 of 31 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.293E-09	4.694E-06	CYP1A1, CYP1B1, CYP2C19, CYP2C9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.331E-09	2.032E-05	CA12, CA14, CA2, CA9, HBB
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	2.959E-08	4.296E-05	AHR, CYP1A1, CYP1B1, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.639E-08	4.953E-05	CYP1A1, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.232E-08	9.434E-05	CYP2C19, CYP2C9, CYP2D6
BP	GO:0050896; response to stimulus	GO:0010038; response to metal ion	7.407E-07	4.887E-04	ALOX15, CA2, CYP1A1, FABP4, KMT2A, NPC1, TP53
BP	GO:0032501; multicellular organismal process	GO:0032922; circadian regulation of gene expression	1.994E-06	1.085E-03	AHR, KMT2A, PPARA, USP2
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	2.538E-06	1.316E-03	AHR, ALOX15, BRCA1, CA2, CYP1A1, CYP1B1, FABP5, GAA, HTT, KMT2A, LMNA, POLB, PPARA, SMN1, SMN2, TP53, USP2
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	2.822E-06	1.365E-03	CYP1A1, CYP1B1, CYP2C19, CYP2C9, CYP2D6, NPC1
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	5.383E-06	2.211E-03	CYP1A1, POLB, TP53

Showing 1 to 10 of 24 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.266E-08	1.038E-06	CA12, CA2, CA9, CA14
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.436E-06	1.486E-04	CYP2C9, CYP2D6, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.322E-05	2.167E-04	CYP2C9, ALOX15, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.320E-04	1.546E-03	CYP2C9, ALOX15, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.814E-04	1.860E-03	CYP2C9, CYP2D6, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	4.337E-06	1.486E-04	FABP3, FABP4, FABP5, PPARA
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.969E-05	4.058E-04	CYP2C9, CYP2D6, ALOX15, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	8.647E-06	1.773E-04	CYP2C9, CYP1A1, CYP1B1, CYP2C19

Showing 1 to 8 of 8 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	TP53; CA9;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Hansenia forbesii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities