Plant Name: Machilus robusta
Taxonomic Information:
Plant ID: NPO2462
Plant Latin Name: Machilus robusta
Taxonomy Genus: Machilus
Taxonomy Family: Lauraceae
Plant External Links:
NCBI TaxonomyDB:
460780
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TDP1; HSD17B10; ALOX15; HPGD; ALDH1A1; | |
| FYN; LCK; EGFR; PRKCD; | |
| THRB; | |
| KDM4E; | |
| CASP7; CASP1; | |
| HIF1A; | |
| XDH; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2D6; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Nuclear hormone receptor subfamily 1 group A | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
| Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
| Protein Kinase | FYN | Tyrosine-protein kinase FYN | P06241 | CHEMBL1841 |
| Protein Kinase | LCK | Tyrosine-protein kinase LCK | P06239 | CHEMBL258 |
| Protein Kinase | EGFR | Epidermal growth factor receptor erbB1 | P00533 | CHEMBL203 |
| Protein Kinase | PRKCD | Protein kinase C delta | Q05655 | CHEMBL2996 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 5.281E-07 | 3.068E-03 | CASP1, CASP7, LCK, XDH |
| MF | GO:0005488; binding | GO:0042610; CD8 receptor binding | 6.433E-07 | 3.068E-03 | FYN, LCK |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 3.627E-06 | 5.794E-03 | ALDH1A1, ALOX15, CYP2D6, HPGD, HSD17B10, KDM4E, XDH |
| BP | GO:0009987; cellular process | GO:0097194; execution phase of apoptosis | 3.865E-06 | 5.794E-03 | CASP1, CASP7, PRKCD |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 7.395E-06 | 7.668E-03 | EGFR, FYN, LCK |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 9.631E-06 | 8.388E-03 | ALOX15, HPGD |
| MF | GO:0003824; catalytic activity | GO:0004715; non-membrane spanning protein tyrosine kinase activity | 9.478E-06 | 8.388E-03 | FYN, LCK, PRKCD |
| BP | GO:0008152; metabolic process | GO:0032270; positive regulation of cellular protein metabolic process | 1.126E-05 | 8.754E-03 | ALOX15, CASP1, CASP7, EGFR, FYN, LCK, PRKCD, XDH |
| MF | GO:0005488; binding | GO:0042608; T cell receptor binding | 1.348E-05 | 9.417E-03 | FYN, LCK |
| MF | GO:0005488; binding | GO:0042609; CD4 receptor binding | 1.348E-05 | 9.417E-03 | FYN, LCK |
| MF | GO:0003824; catalytic activity | GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity | 2.067E-05 | 1.155E-02 | EGFR, FYN, LCK |
| CC | GO:0044464; cell part | GO:0031234; extrinsic component of cytoplasmic side of plasma membrane | 2.686E-05 | 1.315E-02 | ALOX15, FYN, LCK |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 8.693E-04 | 2.829E-02 | CASP7, CASP1 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.287E-03 | 2.829E-02 | HIF1A, EGFR |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.567E-03 | 2.829E-02 | FYN, EGFR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04912 | GnRH signaling pathway | 2.357E-03 | 2.829E-02 | PRKCD, EGFR |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 1.609E-03 | 2.829E-02 | CASP7, CASP1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 2.782E-03 | 2.829E-02 | PRKCD, EGFR |
| 09160 Human Diseases | 09161 Cancers | hsa05231 | Choline metabolism in cancer | 2.893E-03 | 2.829E-02 | HIF1A, EGFR |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 3.007E-03 | 2.829E-02 | HIF1A, EGFR |
| 09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 3.064E-03 | 2.829E-02 | LCK, FYN |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 3.543E-03 | 2.829E-02 | CYP2D6, ALOX15 |
Human Diseases Associated with the Target Proteins of the Plant
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
