Plant Name: Rumex dentatus
Taxonomic Information:
Plant ID: NPO24601
Plant Latin Name: Rumex dentatus
Taxonomy Genus: Rumex
Taxonomy Family: Polygonaceae
Plant External Links:
NCBI TaxonomyDB:
1006352
Plant-of-the-World-Online:
697039-1
Used in Medicines:
Country/Region:
China; IndiaTraditional Medicine System:
TCM; AyurvedaMedicinal Functions:
Astringent
Geographical Distribution:
Bangladesh; South Africa; Egypt; India; France; United States; Tunisia; China; Uganda; Mali
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| GPBAR1; | |
| PTPN1; PTPN2; ACP1; PTPRF; | |
| RECQL; BLM; HSD11B1; AKR1B10; HSD17B10; ALOX15; | |
| MAPK1; PIM1; CSNK2A1; | |
| RORC; | |
| ESR1; ESR2; | |
| NR1H4; | |
| ELANE; | |
| HIF1A; NFKB1; | |
| LMNA; MAPT; THPO; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Nuclear hormone receptor subfamily 3 group A | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | P24666 | CHEMBL4903 |
| Protein Phosphatase | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | P10586 | CHEMBL3521 |
| Serine protease | ELANE | Leukocyte elastase | P08246 | CHEMBL248 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 4.836E-08 | 5.922E-04 | AKR1B10, CYP2C19, CYP2C9, CYP3A4, ESR1, HSD11B1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 5.440E-08 | 5.922E-04 | CYP2C19, CYP2C9, CYP3A4 |
| MF | GO:0005488; binding | GO:0005496; steroid binding | 1.410E-07 | 7.676E-04 | CYP3A4, ESR1, ESR2, NR1H4, RORC |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 5.949E-07 | 2.225E-03 | CYP2C19, CYP2C9, CYP3A4 |
| MF | GO:0060089; molecular transducer activity | GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | 2.026E-06 | 4.412E-03 | ESR1, ESR2 |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 4.785E-06 | 5.788E-03 | ESR1, ESR2, NR1H4, PIM1, RORC |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 6.074E-06 | 6.298E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 6.074E-06 | 6.298E-03 | GPBAR1, NR1H4 |
| MF | GO:0005488; binding | GO:0034056; estrogen response element binding | 1.214E-05 | 1.016E-02 | ESR1, ESR2 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 1.214E-05 | 1.016E-02 | CYP2C9, CYP3A4 |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 1.187E-04 | 2.722E-02 | BLM, CSNK2A1, ESR1, ESR2, HIF1A, LMNA, MAPK1, NFKB1, NR1H4, PIM1, PTPN2, RECQL, RORC |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 1.228E-04 | 2.757E-02 | HIF1A, MAPK1, MAPT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 5.559E-08 | 4.915E-06 | PTPN1, CSNK2A1, MAPK1, ACP1, PTPRF |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 7.124E-08 | 4.915E-06 | CYP2C9, ALOX15, CYP3A4, CYP2C19 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 2.961E-06 | 1.362E-04 | MAPK1, ESR1, NFKB1, ESR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 4.985E-06 | 1.720E-04 | HSD11B1, CYP2C9, CYP3A4, CYP2C19 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.720E-05 | 4.747E-04 | CYP2C9, ALOX15, MAPK1, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 6.835E-05 | 1.572E-03 | PIM1, MAPK1, NFKB1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 8.794E-05 | 1.734E-03 | CYP2C9, ALOX15, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.210E-04 | 2.088E-03 | CYP2C9, CYP3A4, CYP2C19 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3.736E-04 | 4.551E-03 | PIM1, MAPK1, NFKB1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.431E-04 | 2.195E-03 | HSD11B1, CYP2C9, CYP3A4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 3.523E-04 | 4.551E-03 | MAPK1, ESR1, ESR2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 3.957E-04 | 4.551E-03 | MAPK1, HIF1A, NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 4.671E-04 | 4.959E-03 | PTPN1, NFKB1, PTPRF |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 5.889E-04 | 5.805E-03 | MAPK1, ESR1, HIF1A |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 9.674E-04 | 8.344E-03 | LMNA, MAPK1, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 9.476E-04 | 8.344E-03 | PTPN1, MAPK1, PTPRF |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
