CMAUP Plant Collective Molecular Activities

Plant Name: Rosa roxburghii

Taxonomic Information:

Plant ID: NPO24502
Plant Latin Name: Rosa roxburghii
Taxonomy Genus: Rosa
Taxonomy Family: Rosaceae

Plant External Links:

NCBI TaxonomyDB: 74654
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Astringent; Cancer

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	ALOX15; USP2;
Transcription Factor	HIF1A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.205E-06	1.305E-02	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.614E-06	1.312E-02	CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	5.300E-06	1.466E-02	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0032787; monocarboxylic acid metabolic process	5.385E-06	1.466E-02	ALOX15, CYP2C19, CYP2C9, HIF1A
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	1.091E-05	1.988E-02	CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.095E-05	1.988E-02	ALOX15, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.684E-05	2.821E-02	CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	7.913E-05	9.783E-02	CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	6.212E-04	4.227E-01	ALOX15
MF	GO:0005488; binding	GO:0020037; heme binding	6.423E-04	4.238E-01	CYP2C19, CYP2C9
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	2.063E-02	1.000E+00	HIF1A
CC	GO:0044464; cell part	GO:0031234; extrinsic component of cytoplasmic side of plasma membrane	2.216E-02	1.000E+00	ALOX15
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	2.997E-02	1.000E+00	CYP2C19, CYP2C9
CC	GO:0032991; macromolecular complex	GO:0090575; RNA polymerase II transcription factor complex	4.001E-02	1.000E+00	HIF1A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.466E-08	8.745E-07	CYP2C9, ALOX15, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.636E-07	4.509E-06	CYP2C9, ALOX15, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.378E-06	1.801E-05	CYP2C9, ALOX15, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.744E-04	6.976E-04	CYP2C9, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.464E-04	7.886E-04	CYP2C9, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.116E-03	1.098E-02	CYP2C9, ALOX15, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	1.787E-02	3.157E-02	HIF1A
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	1.964E-02	3.157E-02	HIF1A
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.934E-02	3.157E-02	CYP2C9
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.993E-02	3.157E-02	HIF1A

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases