Plant ID: NPO24501
Plant Latin Name: Asteriscus graveolens
Taxonomy Genus: Asteriscus
Taxonomy Family: Asteraceae
NCBI TaxonomyDB:
73976
Plant-of-the-World-Online:
n.a.
DRD3; | |
ALPL; | |
AXL; SRC; IGF1R; PTK2; MAPK1; ALK; KDR; | |
CA2; CA14; | |
NFKB1; |
Cytochrome P450 Enzymes: |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
Protein Kinase | SRC | Tyrosine-protein kinase SRC | P12931 | CHEMBL267 |
Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
Protein Kinase | PTK2 | Focal adhesion kinase 1 | Q05397 | CHEMBL2695 |
Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
Protein Kinase | ALK | ALK tyrosine kinase receptor | Q9UM73 | CHEMBL4247 |
Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
Small molecule receptor (family A GPCR) | DRD3 | Dopamine D3 receptor | P35462 | CHEMBL234 |
Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 1.501E-08 | 4.669E-05 | IGF1R, KDR, PTK2, SRC |
MF | GO:0060089; molecular transducer activity | GO:0004714; transmembrane receptor protein tyrosine kinase activity | 4.671E-08 | 7.824E-05 | ALK, AXL, IGF1R, KDR |
BP | GO:0009987; cellular process | GO:0048010; vascular endothelial growth factor receptor signaling pathway | 8.586E-08 | 1.169E-04 | AXL, KDR, PTK2, SRC |
BP | GO:0009987; cellular process | GO:0035690; cellular response to drug | 4.662E-07 | 4.230E-04 | AXL, KDR, MAPK1, NFKB1, SRC |
BP | GO:0040011; locomotion | GO:0030335; positive regulation of cell migration | 4.254E-06 | 2.370E-03 | IGF1R, KDR, MAPK1, PTK2, SRC |
BP | GO:0022610; biological adhesion | GO:0051893; regulation of focal adhesion assembly | 4.463E-06 | 2.370E-03 | KDR, PTK2, SRC |
BP | GO:0050896; response to stimulus | GO:0010035; response to inorganic substance | 5.281E-06 | 2.613E-03 | AXL, CA2, KDR, MAPK1, SRC |
BP | Unclassified; | GO:2000021; regulation of ion homeostasis | 6.043E-06 | 2.633E-03 | CA2, DRD3, KDR, SRC |
MF | GO:0005488; binding | GO:0005524; ATP binding | 8.470E-06 | 3.236E-03 | ALK, AXL, IGF1R, KDR, MAPK1, PTK2, SRC |
BP | GO:0002376; immune system process | GO:0002684; positive regulation of immune system process | 1.425E-05 | 4.371E-03 | AXL, CA2, MAPK1, NFKB1, PTK2, SRC |
BP | GO:0009987; cellular process | GO:0060159; regulation of dopamine receptor signaling pathway | 1.588E-05 | 4.736E-03 | ALK, DRD3 |
BP | GO:0009987; cellular process | GO:0038127; ERBB signaling pathway | 1.637E-05 | 4.816E-03 | MAPK1, PTK2, SRC |
BP | GO:0009987; cellular process | GO:0045595; regulation of cell differentiation | 2.193E-05 | 5.824E-03 | AXL, CA2, DRD3, KDR, MAPK1, NFKB1, PTK2 |
BP | GO:0050896; response to stimulus | GO:0038166; angiotensin-activated signaling pathway | 2.327E-05 | 6.032E-03 | CA2, SRC |
BP | GO:0009987; cellular process | GO:0014066; regulation of phosphatidylinositol 3-kinase signaling | 2.614E-05 | 6.467E-03 | KDR, MAPK1, PTK2 |
BP | GO:0050896; response to stimulus | GO:0034614; cellular response to reactive oxygen species | 3.605E-05 | 8.198E-03 | AXL, MAPK1, SRC |
BP | GO:0032502; developmental process | GO:0048513; animal organ development | 3.614E-05 | 8.198E-03 | AXL, CA2, KDR, MAPK1, PTK2, SRC |
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 3.698E-05 | 8.302E-03 | CA14, CA2 |
BP | GO:0009987; cellular process | GO:0030168; platelet activation | 3.808E-05 | 8.345E-03 | AXL, MAPK1, SRC |
BP | GO:0009987; cellular process | GO:2000811; negative regulation of anoikis | 4.225E-05 | 8.762E-03 | PTK2, SRC |
BP | GO:0009987; cellular process | GO:0071407; cellular response to organic cyclic compound | 4.728E-05 | 9.532E-03 | ALPL, MAPK1, NFKB1, SRC |
BP | GO:0051179; localization | GO:2000641; regulation of early endosome to late endosome transport | 4.787E-05 | 9.534E-03 | MAPK1, SRC |
BP | GO:0050896; response to stimulus | GO:0071222; cellular response to lipopolysaccharide | 4.816E-05 | 9.534E-03 | AXL, NFKB1, SRC |
BP | GO:0009987; cellular process | GO:0097237; cellular response to toxic substance | 4.938E-05 | 9.687E-03 | AXL, KDR, NFKB1 |
MF | Unclassified; | GO:0005057; signal transducer activity, downstream of receptor | 5.188E-05 | 9.997E-03 | ALK, KDR, MAPK1 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 3.806E-08 | 3.168E-06 | SRC, KDR, MAPK1, PTK2 |
09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 7.666E-08 | 3.168E-06 | SRC, KDR, MAPK1, PTK2, IGF1R |
09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04510 | Focal adhesion | 7.479E-08 | 3.168E-06 | SRC, KDR, MAPK1, PTK2, IGF1R |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 1.004E-06 | 3.114E-05 | KDR, MAPK1, PTK2, NFKB1, IGF1R |
09150 Organismal Systems | 09151 Immune system | hsa04062 | Chemokine signaling pathway | 3.455E-06 | 8.568E-05 | SRC, MAPK1, NFKB1, PTK2 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 5.578E-06 | 1.153E-04 | SRC, KDR, MAPK1, IGF1R |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 7.449E-06 | 1.155E-04 | KDR, MAPK1, NFKB1, IGF1R |
09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 9.615E-06 | 1.295E-04 | SRC, MAPK1, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 7.059E-06 | 1.155E-04 | SRC, MAPK1, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.820E-05 | 1.881E-04 | MAPK1, NFKB1, IGF1R |
09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.044E-05 | 1.295E-04 | SRC, MAPK1, IGF1R |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04012 | ErbB signaling pathway | 1.700E-05 | 1.881E-04 | SRC, MAPK1, PTK2 |
09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 6.672E-05 | 5.516E-04 | MAPK1, NFKB1, PTK2, IGF1R |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 2.822E-05 | 2.691E-04 | MAPK1, NFKB1, IGF1R |
09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 7.989E-05 | 6.191E-04 | SRC, MAPK1, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 2.181E-04 | 1.423E-03 | SRC, MAPK1, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05152 | Tuberculosis | 1.437E-04 | 1.024E-03 | SRC, MAPK1, NFKB1 |
09140 Cellular Processes | 09142 Cell motility | hsa04810 | Regulation of actin cytoskeleton | 2.475E-04 | 1.534E-03 | SRC, MAPK1, PTK2 |
09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 1.486E-04 | 1.024E-03 | NFKB1, PTK2, IGF1R |
09140 Cellular Processes | 09141 Transport and catabolism | hsa04144 | Endocytosis | 4.331E-04 | 2.441E-03 | SRC, KDR, IGF1R |
09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 4.992E-04 | 2.565E-03 | ALK, MAPK1 |
09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 6.722E-04 | 3.069E-03 | MAPK1, IGF1R |
09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 5.171E-04 | 2.565E-03 | MAPK1, NFKB1 |
09150 Organismal Systems | 09156 Nervous system | hsa04730 | Long-term depression | 5.729E-04 | 2.732E-03 | MAPK1, IGF1R |
09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 6.929E-04 | 3.069E-03 | MAPK1, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 2.671E-04 | 1.577E-03 | SRC, MAPK1 |
09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 8.470E-04 | 3.183E-03 | MAPK1, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 8.014E-04 | 3.183E-03 | MAPK1, IGF1R |
09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 5.171E-04 | 2.565E-03 | MAPK1, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 7.354E-04 | 3.145E-03 | SRC, NFKB1 |
09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 8.470E-04 | 3.183E-03 | MAPK1, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 8.470E-04 | 3.183E-03 | MAPK1, NFKB1 |
09150 Organismal Systems | 09152 Endocrine system | hsa04912 | GnRH signaling pathway | 1.312E-03 | 4.171E-03 | SRC, MAPK1 |
09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.612E-03 | 4.544E-03 | MAPK1, NFKB1 |
09150 Organismal Systems | 09152 Endocrine system | hsa04914 | Progesterone-mediated oocyte maturation | 1.519E-03 | 4.544E-03 | MAPK1, IGF1R |
09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 1.399E-03 | 4.337E-03 | NFKB1, IGF1R |
09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 1.173E-03 | 3.931E-03 | NFKB1, PTK2 |
09160 Human Diseases | 09167 Infectious diseases | hsa05100 | Bacterial invasion of epithelial cells | 9.662E-04 | 3.423E-03 | SRC, PTK2 |
09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 1.550E-03 | 4.544E-03 | SRC, MAPK1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 8.938E-04 | 3.260E-03 | MAPK1, NFKB1 |
09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04540 | Gap junction | 1.228E-03 | 4.006E-03 | SRC, MAPK1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05132 | Salmonella infection | 1.173E-03 | 3.931E-03 | MAPK1, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05146 | Amoebiasis | 1.581E-03 | 4.544E-03 | NFKB1, PTK2 |
09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 1.708E-03 | 4.605E-03 | MAPK1, NFKB1 |
09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 1.774E-03 | 4.680E-03 | MAPK1, NFKB1 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 1.908E-03 | 4.930E-03 | MAPK1, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05142 | Chagas disease (American trypanosomiasis) | 1.708E-03 | 4.605E-03 | MAPK1, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 2.192E-03 | 5.402E-03 | MAPK1, NFKB1 |
09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 2.265E-03 | 5.402E-03 | MAPK1, NFKB1 |
09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 2.192E-03 | 5.402E-03 | SRC, MAPK1 |
09150 Organismal Systems | 09151 Immune system | hsa04611 | Platelet activation | 2.340E-03 | 5.461E-03 | SRC, MAPK1 |
09140 Cellular Processes | 09143 Cell growth and death | hsa04114 | Oocyte meiosis | 2.378E-03 | 5.461E-03 | MAPK1, IGF1R |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 2.265E-03 | 5.402E-03 | MAPK1, NFKB1 |
09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 3.067E-03 | 6.445E-03 | MAPK1, NFKB1 |
09150 Organismal Systems | 09158 Development | hsa04380 | Osteoclast differentiation | 2.732E-03 | 5.929E-03 | MAPK1, NFKB1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 2.773E-03 | 5.929E-03 | MAPK1, NFKB1 |
09150 Organismal Systems | 09158 Development | hsa04360 | Axon guidance | 2.533E-03 | 5.710E-03 | MAPK1, PTK2 |
09150 Organismal Systems | 09152 Endocrine system | hsa04921 | Oxytocin signaling pathway | 3.886E-03 | 7.899E-03 | SRC, MAPK1 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 2.773E-03 | 5.929E-03 | MAPK1, IGF1R |
09160 Human Diseases | 09167 Infectious diseases | hsa05164 | Influenza A | 4.743E-03 | 9.486E-03 | MAPK1, NFKB1 |
09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 3.153E-03 | 6.517E-03 | MAPK1, IGF1R |
09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 4.466E-05 | 3.955E-04 | CA2, CA14 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |
C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR; |
C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | PTK2; |
C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | IGF1R; KDR; AXL; |
C00-D49: Neoplasms | Glioma | C71 | KDR; |
C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | DRD3; |
L00-L99: Diseases of the skin and subcutaneous tissue | Psoriatic disorder | L40 | IGF1R; |
C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR; |
C00-D49: Neoplasms | Brain cancer | C71, D33 | SRC; |
C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | KDR; |
C00-D49: Neoplasms | Pancreatic cancer | C25 | KDR; |
C00-D49: Neoplasms | Solid tumours | C00-D48 | PTK2; IGF1R; KDR; MAPK1; SRC; |
C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR; |
C00-D49: Neoplasms | Non-small-cell lung cancer | NA | KDR; |
C00-D49: Neoplasms | Multiple myeloma | C90 | IGF1R; SRC; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | DRD3; |
C00-D49: Neoplasms | Thyroid cancer | C73 | KDR; |
G00-G99: Diseases of the nervous system G00-G99 | Motor neurone disease | G12.2 | IGF1R; |
C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR; |
C00-D49: Neoplasms | Glioblastoma multiforme | C71 | SRC; |
G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | IGF1R; |
C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
C00-D49: Neoplasms | Colorectal cancer | C18-C21 | IGF1R; KDR; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Growth failure | R62.8 | IGF1R; |
C00-D49: Neoplasms | Malignant adrenal gland cancer | C74.0 | IGF1R; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Male sexual disorders | F52 | DRD3; |
C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR; |
C00-D49: Neoplasms | Gastric cancer | C16 | KDR; |
K00-K95: Diseases of the digestive system | Gastric motility disorder | K22.4 | DRD3; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Female sexual dysfunction | F52 | DRD3; |
C00-D49: Neoplasms | AML | NA | KDR; |
C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR; |
C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR; |
C00-D49: Neoplasms | Metastasis | C00-C97 | AXL; |
C00-D49: Neoplasms | Mesothelioma | C45 | PTK2; |
C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR; |
H00-H59: Diseases of the eye and adnexa | Graves' ophthalmopathy | H06.2 | IGF1R; |
C00-D49: Neoplasms | Liver cancer | C22 | IGF1R; KDR; |
I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; |
C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | KDR; |
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Emesis | R11 | DRD3; |
NA: NA | Edema | NA | CA2; |
I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2; |
K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; |
C00-D49: Neoplasms | Breast cancer | C50 | IGF1R; KDR; |
C00-D49: Neoplasms | Osteosarcoma | C40-C41 | SRC; |
C00-D49: Neoplasms | Ovarian cancer | C56 | KDR; |
I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | SRC; |
C00-D49: Neoplasms | Hematological malignancies | C81-C86 | SRC; |
C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | IGF1R; KDR; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Drug abuse | F10-F19 | DRD3; |
C00-D49: Neoplasms | Chronic myelogenous leukaemia | C92.1 | SRC; |
C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cocaine addiction | F14.2 | DRD3; |
I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2; |
E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | IGF1R; |
M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | SRC; |
I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1; |
C00-D49: Neoplasms | Advanced breast cancer | C50 | SRC; |
H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; |
C00-D49: Neoplasms | Renal cancer | C64 | KDR; |
I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | KDR; |
C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR; |
E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
C00-D49: Neoplasms | Renal cell carcinoma | NA | KDR; |
C00-D49: Neoplasms | Cancer | C00-C96 | PTK2; IGF1R; KDR; NFKB1; MAPK1; SRC; |
C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR; |
C00-D49: Neoplasms | Melanoma | C43 | KDR; |