CMAUP Plant Collective Molecular Activities

Plant Name: Lobelia inflata

Taxonomic Information:

Plant ID: NPO24373
Plant Latin Name: Lobelia inflata
Taxonomy Genus: Lobelia
Taxonomy Family: Campanulaceae

Plant External Links:

NCBI TaxonomyDB: 308559
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

TCM; Homeopathy

Medicinal Functions:

Antiasthmatic; Antispasmodic; Diaphoretic; Diuretic; Emetic; Expectorant; Miscellany; Nervine

Geographical Distribution:

India; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA;
Nicotinic acetylcholine receptor	CHRNA7;
Lyase	CA2; CA1; CA7; CA4; CA6; CA12; CA9; CA14;
Transcription Factor	HIF1A;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Nicotinic acetylcholine receptor	CHRNA7	Neuronal acetylcholine receptor protein alpha-7 subunit	P36544	CHEMBL2492
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.091E-06	1.584E-03	CA1, CA12, CA2, CA4, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.688E-06	2.297E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.428E-06	9.176E-03	CYP1A2, CYP2D6
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	8.428E-06	9.176E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.609E-23	1.875E-18	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.349E-18	2.557E-14	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.673E-16	1.164E-12	CA1, CA12, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.179E-05	1.223E-02	CYP1A2, CYP2D6
MF	GO:0005488; binding	GO:0043169; cation binding	2.963E-05	2.688E-02	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CHRNA7, CYP1A2, CYP2D6

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.460E-22	9.103E-21	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.316E-04	2.435E-03	CA2, CA4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.196E-03	1.238E-02	CYP2D6, CYP1A2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.338E-03	1.238E-02	CYP2D6, CYP1A2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.684E-03	1.246E-02	CHRNA7, CYP1A2
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	2.007E-02	9.157E-02	CA2
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	2.959E-02	9.954E-02	CHRNA7
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.154E-02	9.157E-02	CYP1A2
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.227E-02	9.157E-02	GAA
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.745E-03	2.309E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6; CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases