CMAUP Plant Collective Molecular Activities

Plant Name: Paeonia veitchii

Taxonomic Information:

Plant ID: NPO24267
Plant Latin Name: Paeonia veitchii
Taxonomy Genus: Paeonia
Taxonomy Family: Paeoniaceae

Plant External Links:

NCBI TaxonomyDB: 40722
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Analgesic; Antibacterial; Antiinflammatory; Antispasmodic; Diuretic; Febrifuge; Sedative

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Transient receptor potential channel	TRPA1;
Protein Kinase	MAPK1;
Lyase	CA1; CA5B; CA5A; CA6; CA12;
Oxidoreductase	HMGCR;
Enzyme_unclassified	ALDH1A1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A6; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Oxidoreductase	HMGCR	HMG-CoA reductase	P04035	CHEMBL402
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.720E-13	3.745E-09	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.143E-11	2.334E-07	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.157E-11	4.469E-07	CA1, CA12, CA5A, CA5B, CA6
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	2.019E-06	5.494E-03	CA1, CA12, CA5A, CA5B, CA6, CYP2A6, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.976E-13	3.184E-11	CA12, CA1, CA5B, CA5A, CA6
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.155E-06	4.898E-04	CYP2A6, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3.972E-04	1.417E-02	CYP2A6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8.928E-04	1.781E-02	CYP2A6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9.986E-04	1.781E-02	CYP2A6, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	9.450E-04	1.781E-02	HMGCR, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.258E-03	1.923E-02	CYP2A6, CYP3A4
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.608E-03	4.289E-02	LMNA, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	7.149E-03	6.954E-02	MAPK1, TSHR
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.246E-03	4.289E-02	CYP2A6

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases