Plant Name: Taiwania cryptomerioides
Taxonomic Information:
Plant ID: NPO24241
Plant Latin Name: Taiwania cryptomerioides
Taxonomy Genus: Taiwania
Taxonomy Family: Cupressaceae
Plant External Links:
NCBI TaxonomyDB:
50187
Plant-of-the-World-Online:
263753-1
Used in Medicines:
Unknown.
Geographical Distribution:
Taiwan; Vietnam; China; Myanmar
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2C19; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Protein Kinase | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Q02750 | CHEMBL3587 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006690; icosanoid metabolic process | 8.583E-05 | 5.538E-01 | ALOX5, CYP2C19 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 2.034E-04 | 5.538E-01 | ALOX5, CYP2C19 |
| BP | GO:0050896; response to stimulus | GO:1903034; regulation of response to wounding | 2.587E-02 | 1.000E+00 | MAP2K1 |
| BP | GO:0032501; multicellular organismal process | GO:0007507; heart development | 2.678E-02 | 1.000E+00 | MAP2K1 |
| BP | GO:0008152; metabolic process | GO:0018108; peptidyl-tyrosine phosphorylation | 2.861E-02 | 1.000E+00 | MAP2K1 |
| CC | GO:0044464; cell part | GO:0005641; nuclear envelope lumen | 1.242E-03 | 1.000E+00 | ALOX5 |
| CC | GO:0044464; cell part | GO:0005770; late endosome | 2.082E-02 | 1.000E+00 | MAP2K1 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 5.272E-03 | 1.000E+00 | CYP2C19 |
| MF | GO:0003824; catalytic activity | GO:0004712; protein serine/threonine/tyrosine kinase activity | 6.509E-03 | 1.000E+00 | MAP2K1 |
| MF | GO:0003824; catalytic activity | GO:0016791; phosphatase activity | 4.165E-02 | 1.000E+00 | MAP2K1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.710E-07 | 1.197E-05 | MAP2K1, ALOX5, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 2.831E-05 | 9.908E-04 | ALOX5, CYP2C19 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04914 | Progesterone-mediated oocyte maturation | 1.463E-02 | 2.723E-02 | MAP2K1 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04540 | Gap junction | 1.314E-02 | 2.723E-02 | MAP2K1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04666 | Fc gamma R-mediated phagocytosis | 1.389E-02 | 2.723E-02 | MAP2K1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 1.478E-02 | 2.723E-02 | MAP2K1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04916 | Melanogenesis | 1.493E-02 | 2.723E-02 | MAP2K1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.225E-02 | 2.723E-02 | CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05231 | Choline metabolism in cancer | 1.507E-02 | 2.723E-02 | MAP2K1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 1.656E-02 | 2.723E-02 | MAP2K1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | ALOX5; |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | ALOX5; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | ALOX5; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | ALOX5; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | ALOX5; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | ALOX5; |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | ALOX5; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | ALOX5; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ALOX5; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | ALOX5; |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5; |
| J00-J99: Diseases of the respiratory system | Respiratory disease | J00-J99 | ALOX5; |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | ALOX5; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | ALOX5; |
| J00-J99: Diseases of the respiratory system | Rhinitis | J00, J30, J31.0 | ALOX5; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | ALOX5; |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | ALOX5; |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
