CMAUP Plant Collective Molecular Activities

Plant Name: Tylophora asthmatica

Taxonomic Information:

Plant ID: NPO24043
Plant Latin Name: Tylophora asthmatica
Taxonomy Genus: Tylophora
Taxonomy Family: Apocynaceae

Plant External Links:

NCBI TaxonomyDB: 1266040
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; Philippines; India

Traditional Medicine System:

Indian Folk; TCM; Homeopathy; Ayurveda; Siddha

Geographical Distribution:

India; Philippines; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	PKM;
Oxidoreductase	PTGS1; PTGS2;
Transcription Factor	JUN;
Unclassified	LMNA; NPC1; THPO; RAB9A;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP3A4; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Transcription Factor	JUN	Proto-oncogene c-JUN	P05412	CHEMBL4977
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0020037; heme binding	5.176E-12	5.635E-08	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, PTGS1, PTGS2
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.572E-11	2.862E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.338E-10	5.657E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.863E-09	3.120E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.753E-09	4.282E-06	CYP1A1, CYP1A2, CYP1B1, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.312E-09	1.267E-05	CYP1A2, CYP2C19, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.021E-07	9.668E-05	CYP1A2, CYP2C19, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.486E-07	1.294E-04	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	2.370E-07	1.912E-04	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, PTGS1, PTGS2, RAB9A
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	6.433E-07	4.584E-04	PTGS1, PTGS2
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	8.175E-07	5.563E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	1.929E-06	1.135E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.856E-06	1.908E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.856E-06	1.908E-03	CYP1A2, CYP3A4
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	5.217E-06	2.469E-03	CYP1A1, CYP1A2, CYP1B1, JUN, LMNA, PKM, PTGS2, SMN1, SMN2, THPO, TSHR
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	6.423E-06	2.797E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	9.631E-06	3.957E-03	CYP1A1, CYP3A4
CC	GO:0016020; membrane	GO:0031090; organelle membrane	1.055E-05	4.179E-03	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, LMNA, NPC1, PTGS1, PTGS2, RAB9A
BP	GO:0050896; response to stimulus	GO:0046686; response to cadmium ion	1.258E-05	4.893E-03	CYP1A2, JUN, NPC1
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.348E-05	5.148E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.796E-05	6.518E-03	CYP1A1, CYP1A2
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	4.225E-05	1.353E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	4.991E-05	1.489E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	9.766E-05	2.444E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.056E-11	2.353E-09	CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19, PTGS2
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.129E-07	4.346E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.875E-07	7.380E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.076E-06	6.277E-05	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	8.047E-06	1.033E-04	CYP1A1, CYP1B1, PTGS2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.516E-06	2.917E-05	CYP1A2, CYP3A4, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.135E-05	1.248E-04	PTGS2, TSHR, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.544E-05	1.486E-04	CYP2C19, PTGS2, PTGS1
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.398E-05	1.679E-04	PKM, CYP1A2, CYP1A1, PTGS2, CYP2C19, CYP3A4, PTGS1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.780E-05	1.523E-04	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.131E-05	1.641E-04	CYP1A2, CYP3A4, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	9.078E-05	5.825E-04	CYP2C19, PTGS2, PTGS1
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	1.526E-03	9.036E-03	JUN, PTGS2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2;
C00-D49: Neoplasms	Cancer	C00-C96	PTGS2;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PTGS2; JUN;
J00-J99: Diseases of the respiratory system	Asthma	J45	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTGS2;
NA: NA	Rheumatold arthritis	NA	PTGS2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS2;
NA: NA	Joint and muscular pain	NA	PTGS2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS2;
C00-D49: Neoplasms	Pancreatic cancer	C25	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS2;
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases