Plant Name: Cyclamen neapolitanum
Taxonomic Information:
Plant ID: NPO23989
Plant Latin Name: Cyclamen neapolitanum
Taxonomy Genus: Cyclamen
Taxonomy Family: Primulaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| NR1H4; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 3.106E-04 | 2.818E-01 | TSHR |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 4.659E-04 | 3.382E-01 | NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.087E-03 | 5.379E-01 | NR1H4 |
| MF | GO:0005488; binding | GO:0046965; retinoid X receptor binding | 2.328E-03 | 7.347E-01 | NR1H4 |
| MF | GO:0005488; binding | GO:0016922; ligand-dependent nuclear receptor binding | 3.258E-03 | 8.347E-01 | NR1H4 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 2.861E-02 | 1.000E+00 | TSHR |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 4.918E-02 | 1.000E+00 | TSHR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 7.929E-03 | 1.920E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 8.377E-03 | 1.920E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.061E-02 | 1.920E-02 | TSHR |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 1.920E-02 | NR1H4 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.106E-02 | 1.920E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.240E-02 | 1.920E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.344E-02 | 1.920E-02 | LMNA |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.085E-02 | 2.607E-02 | LMNA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 2.956E-02 | 3.284E-02 | TSHR |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 4.098E-02 | 4.098E-02 | TSHR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
