CMAUP Plant Collective Molecular Activities

Plant Name: Anthocleista grandiflora

Taxonomic Information:

Plant ID: NPO23916
Plant Latin Name: Anthocleista grandiflora
Taxonomy Genus: Anthocleista
Taxonomy Family: Gentianaceae

Plant External Links:

NCBI TaxonomyDB: 28539
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Africa

Traditional Medicine System:

Geographical Distribution:

South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA2; CA12; CA1; CA9;
Nuclear hormone receptor subfamily 3 group C	AR;
Enzyme_unclassified	ALOX15; HPGD; TNKS; PARP1; TNKS2;
Transcription Factor	TP53;
Unclassified	RAB9A; NPC1; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A1; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	PARP1	Poly [ADP-ribose] polymerase-1	P09874	CHEMBL3105
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Nuclear hormone receptor subfamily 3 group C	AR	Androgen Receptor	P10275	CHEMBL1871
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.569E-10	6.064E-06	CA1, CA12, CA2, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.376E-08	7.392E-05	CA1, CA12, CA2, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.453E-08	1.484E-04	CA1, CA12, CA2, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.650E-07	3.266E-04	AR, CA1, CA12, CA2, CA9, PARP1, TNKS, TP53
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	9.919E-07	1.440E-03	CYP19A1, CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0003950; NAD+ ADP-ribosyltransferase activity	1.454E-06	1.583E-03	PARP1, TNKS, TNKS2
BP	GO:0065007; biological regulation	GO:1904357; negative regulation of telomere maintenance via telomere lengthening	1.635E-06	1.695E-03	PARP1, TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	4.370E-06	3.172E-03	TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.370E-06	3.172E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0019825; oxygen binding	7.853E-06	5.344E-03	CYP19A1, CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0005506; iron ion binding	9.921E-06	6.209E-03	ALOX15, CYP19A1, CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0070212; protein poly-ADP-ribosylation	1.091E-05	6.254E-03	PARP1, TNKS
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	1.091E-05	6.254E-03	ALOX15, HPGD
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.091E-05	6.254E-03	CA1, CA2
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.035E-05	9.847E-03	CYP1A1, CYP1A2
CC	GO:0016020; membrane	GO:0016020; membrane	6.198E-05	2.142E-02	ALOX15, AR, CA12, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, HPGD, MAPT, NPC1, PARP1, RAB9A, TNKS, TNKS2
CC	GO:0043226; organelle	GO:0000242; pericentriolar material	1.372E-04	3.557E-02	TNKS, TNKS2
CC	GO:0043226; organelle	GO:0000784; nuclear chromosome, telomeric region	1.934E-04	4.479E-02	PARP1, TNKS, TNKS2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.442E-10	4.981E-08	CA12, CA1, CA2, CA9
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.529E-05	4.511E-04	CYP1A2, CYP1A1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.204E-04	7.677E-03	CYP1A2, CYP1A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.724E-04	5.357E-03	CYP1A2, ALOX15
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	8.133E-04	9.597E-03	CYP1A1, CYP19A1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.371E-03	1.348E-02	CYP1A2, CYP1A1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	2.550E-03	1.671E-02	AR, TP53
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.725E-03	1.454E-02	CYP1A2, CYP1A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.170E-03	1.600E-02	CYP1A2, CYP1A1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.243E-03	2.503E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Breast cancer	C50	AR;
C00-D49: Neoplasms	Prostate cancer	C61	AR;
N00-N99: Diseases of the genitourinary system	Prostate hyperplasia	N40	AR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
K00-K95: Diseases of the digestive system	Alcoholic hepatitis	K70.1	AR;
L00-L99: Diseases of the skin and subcutaneous tissue	Alopecia	L65.9	AR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	AR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	AR;
E00-E89: Endocrine, nutritional and metabolic diseases	Testosterone deficiency	E29.1	AR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	AR;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	AR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	AR;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	AR;
E00-E89: Endocrine, nutritional and metabolic diseases	Male hormonal deficiencies	E20-E35	AR;
NA: NA	Male hypogonadism	NA	AR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis in post-menopausal women	M80-M81	AR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	AR;
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	AR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
I00-I99: Diseases of the circulatory system	Heart failure	I50	AR;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	AR;
C00-D49: Neoplasms	Bladder cancer	C67	AR;
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	AR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Muscle atrophy	M62.5	AR;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;
C00-D49: Neoplasms	Female androgenresponsive recurrent mammary cancer	C50	AR;
C00-D49: Neoplasms	Advanced prostate cancer	C61	AR;
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	AR;
C00-D49: Neoplasms	Metastatic prostate cancer	C61	AR;
C00-D49: Neoplasms	Castration-resistant prostate cancer	C61	AR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	AR;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	AR;
C00-D49: Neoplasms	Cancer	C00-C96	AR; TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases