CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA;
Lyase	CA2; CA1; CA7; CA4; CA6; CA12; CA9; CA14;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Showing 1 to 10 of 10 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.235E-07	9.267E-04	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.656E-20	1.803E-16	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.018E-18	2.185E-14	CA1, CA12, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	1.083E-05	1.179E-02	CA2, CA7
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	1.876E-05	1.945E-02	CA2, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.450E-08	5.335E-05	CA1, CA12, CA2, CA4, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.614E-06	4.142E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.030E-25	1.313E-20	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.724E-24	2.069E-23	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2.766E-02	6.240E-02	GAA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.490E-02	4.471E-02	GAA
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	5.984E-02	7.978E-02	GAA
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.661E-05	3.397E-04	CA2, CA4
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	1.342E-02	4.471E-02	CA2
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	3.640E-02	6.240E-02	CA2
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.495E-02	6.240E-02	CA2
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	4.699E-02	7.048E-02	CA2
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	8.091E-02	9.709E-02	MAPT

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Edema	NA	CA2;

Showing 1 to 6 of 6 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Pulicaria insignis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities