Plant Name: Taxus x media
Taxonomic Information:
Plant ID: NPO23840
Plant Latin Name: Taxus x media
Taxonomy Genus: Taxus
Taxonomy Family: Taxaceae
Plant External Links:
NCBI TaxonomyDB:
85957
Plant-of-the-World-Online:
n.a.
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0071404; cellular response to low-density lipoprotein particle stimulus | 1.449E-03 | 1.000E+00 | NPC1 |
| BP | Unclassified; | GO:2000188; regulation of cholesterol homeostasis | 1.449E-03 | 1.000E+00 | NPC1 |
| BP | GO:0051179; localization | GO:0033344; cholesterol efflux | 2.484E-03 | 1.000E+00 | NPC1 |
| BP | GO:0007610; behavior | GO:0007628; adult walking behavior | 2.794E-03 | 1.000E+00 | NPC1 |
| BP | GO:0050896; response to stimulus | GO:0046686; response to cadmium ion | 5.790E-03 | 1.000E+00 | NPC1 |
| BP | GO:0065007; biological regulation | GO:0042632; cholesterol homeostasis | 6.822E-03 | 1.000E+00 | NPC1 |
| BP | GO:0009987; cellular process | GO:0071383; cellular response to steroid hormone stimulus | 7.648E-03 | 1.000E+00 | NPC1 |
| BP | GO:0008152; metabolic process | GO:0006486; protein glycosylation | 2.868E-02 | 1.000E+00 | NPC1 |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 1.043E-02 | 1.000E+00 | RAB9A |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 1.681E-02 | 1.000E+00 | NPC1 |
| CC | GO:0044421; extracellular region part | GO:0070062; extracellular exosome | 2.116E-02 | 1.000E+00 | NPC1, RAB9A |
| CC | GO:0016020; membrane | GO:0045121; membrane raft | 3.011E-02 | 1.000E+00 | NPC1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 1.355E-02 | 1.355E-02 | RAB9A |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 1.226E-02 | 1.355E-02 | NPC1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
