CMAUP Plant Collective Molecular Activities

Plant Name: Swertia angustifolia

Taxonomic Information:

Plant ID: NPO23835
Plant Latin Name: Swertia angustifolia
Taxonomy Genus: Swertia
Taxonomy Family: Gentianaceae

Plant External Links:

NCBI TaxonomyDB: 166611
Plant-of-the-World-Online: 370793-1

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

Indian Folk; TCM; Unani; Ayurveda

Geographical Distribution:

Pakistan; Myanmar; Nepal; India; Vietnam; China; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Peptide receptor (family A GPCR)	NPSR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF;
Enzyme_unclassified	RECQL; HSD11B1; AKR1B10;
Hydrolase	GAA;
Lyase	CA2; CA1; CA12; CA9; CA14; CA7; CA4; CA6;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	MAOA;
Unclassified	HTT; LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.893E-08	4.581E-05	CA1, CA12, CA2, CA4, CA6, CA7, CA9, NR1H4, PTPN1, RORC
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	7.429E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.435E-06	7.429E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	4.435E-06	7.429E-03	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	6.376E-06	9.917E-03	ACP1, PTPN1, PTPN2, PTPRF
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.810E-21	2.136E-16	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.645E-16	2.880E-12	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.421E-14	7.735E-11	CA1, CA12, CA2, CA4, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.213E-05	2.190E-02	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	4.124E-05	3.742E-02	ACP1, PTPN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.802E-20	1.177E-18	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	9.307E-05	1.954E-03	PTPN1, ACP1, PTPRF
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.438E-04	4.814E-03	CA2, CA4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.881E-04	6.175E-03	AKR1B10, GAA
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.260E-03	2.739E-02	CA2, NR1H4
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	7.512E-03	5.258E-02	PTPN1, PTPRF
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	1.198E-02	7.185E-02	PTPN1, PTPRF
09100 Metabolism	09105 Amino acid metabolism	hsa00360	Phenylalanine metabolism	2.021E-02	1.061E-01	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4.694E-02	1.232E-01	MAOA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3.772E-02	1.232E-01	AKR1B10

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1;
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases