CMAUP Plant Collective Molecular Activities

Plant Name: Elsholtzia splendens

Taxonomic Information:

Plant ID: NPO23814
Plant Latin Name: Elsholtzia splendens
Taxonomy Genus: Elsholtzia
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 475396
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Diuretic; Febrifuge

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Hydrolase	ACHE;
Transient receptor potential channel	TRPA1;
Protein Kinase	MAPK1;
Oxidoreductase	PTGS1;
Enzyme_unclassified	ALDH1A1;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A6; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.588E-05	1.581E-01	CYP2A6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0060397; JAK-STAT cascade involved in growth hormone signaling pathway	2.524E-05	1.581E-01	MAPK1, PTPN1
BP	GO:0008152; metabolic process	GO:0044255; cellular lipid metabolic process	6.351E-05	1.581E-01	ACHE, ALDH1A1, CYP2A6, CYP3A4, PTGS1
BP	GO:0051179; localization	GO:0032880; regulation of protein localization	8.631E-05	1.581E-01	ACHE, LMNA, MAPK1, MAPT, PTPN1
BP	GO:0008152; metabolic process	GO:0042445; hormone metabolic process	9.872E-05	1.581E-01	ACHE, ALDH1A1, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	3.297E-05	1.581E-01	CYP2A6, CYP3A4, PTGS1
MF	GO:0005488; binding	GO:0019902; phosphatase binding	6.902E-05	1.581E-01	MAPK1, MAPT, PTPN1
MF	GO:0003824; catalytic activity	GO:0016712; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	7.788E-05	1.581E-01	CYP2A6, CYP3A4
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	9.053E-05	1.581E-01	MAPT, PTPN1
BP	GO:0050896; response to stimulus	GO:0006950; response to stress	1.547E-04	2.011E-01	ACHE, LMNA, MAPK1, MAPT, PTGS1, PTPN1, TRPA1
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	5.239E-04	2.925E-01	MAPK1, MAPT
CC	GO:0016020; membrane	GO:0016020; membrane	1.767E-03	4.526E-01	ACHE, CYP2A6, CYP3A4, LMNA, MAPK1, MAPT, PTGS1, PTPN1, TRPA1
CC	GO:0044464; cell part	GO:0032421; stereocilium bundle	2.586E-03	4.816E-01	TRPA1
CC	GO:0044464; cell part	GO:0097443; sorting endosome	3.103E-03	5.278E-01	PTPN1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.868E-06	4.023E-04	CYP2A6, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2.302E-04	1.197E-02	CYP2A6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5.185E-04	1.240E-02	CYP2A6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.802E-04	1.240E-02	CYP2A6, CYP3A4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	5.962E-04	1.240E-02	PTPN1, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	1.334E-03	1.766E-02	ACHE, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.358E-03	1.766E-02	MAPK1, PTGS1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	7.315E-04	1.268E-02	CYP2A6, CYP3A4
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	1.608E-03	1.859E-02	MAPK1, PTGS1
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.276E-03	1.972E-02	CYP2A6, ALDH1A1, CYP3A4, PTGS1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases