CMAUP Plant Collective Molecular Activities

Plant Name: Litsea zeylanica

Taxonomic Information:

Plant ID: NPO23759
Plant Latin Name: Litsea zeylanica
Taxonomy Genus: Litsea
Taxonomy Family: Lauraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Indian Folk

Geographical Distribution:

India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF; CDC25B;
Enzyme_unclassified	AMY1A;AMY1B;AMY1C; RECQL; PLA2G1B; TDP1; HSD11B1; AKR1B10; GFER; POLB;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Serine protease	F10;
Aspartic protease	BACE1;
Transferase	FUT7;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Enzyme_unclassified	AMY1A;AMY1B;AMY1C	Salivary alpha-amylase	P04745	CHEMBL2478
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Serine protease	F10	Coagulation factor X	P00742	CHEMBL244
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.484E-09	7.587E-05	CA12, CA2, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0004556; alpha-amylase activity	2.161E-08	1.176E-04	AMY1A, AMY1B, AMY1C
MF	Unclassified;	GO:0103025; alpha-amylase activity (releasing maltohexaose)	2.161E-08	1.176E-04	AMY1A, AMY1B, AMY1C
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.475E-07	4.588E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.929E-07	5.250E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.375E-07	7.348E-04	CA12, CA2, CA4, CA7
BP	GO:0032501; multicellular organismal process	GO:0007586; digestion	2.783E-06	4.329E-03	AKR1B10, AMY1A, AMY1B, AMY1C
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.222E-06	5.415E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	5.222E-06	5.415E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	5.222E-06	5.415E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	1.044E-05	9.377E-03	PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0008152; metabolic process	1.077E-05	9.377E-03	ACP1, AKR1B10, AMY1A, AMY1B, AMY1C, BACE1, CA12, CA2, CA4, CA7, CDC25B, F10, FUT7, GFER, HSD11B1, NR1H4, PLA2G1B, POLB, PTPN1, PTPN2, PTPRF, RECQL, RORC, TDP1
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	4.854E-05	3.645E-02	ACP1, PTPN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.278E-09	2.481E-07	CA12, CA2, CA4, CA7
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5.165E-05	8.091E-04	AMY1A, AMY1B, AMY1C
09150 Organismal Systems	09154 Digestive system	hsa04973	Carbohydrate digestion and absorption	2.669E-05	6.272E-04	AMY1A, AMY1B, AMY1C
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.189E-04	1.397E-03	PTPN1, ACP1, PTPRF
09150 Organismal Systems	09154 Digestive system	hsa04970	Salivary secretion	2.057E-04	1.933E-03	AMY1A, AMY1B, AMY1C
Unclassified	Unclassified	hsa01100	Metabolic pathways	7.979E-04	5.358E-03	HSD11B1, FUT7, AKR1B10, PLA2G1B, AMY1A, AMY1B, AMY1C
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4.043E-04	3.167E-03	CA2, CA4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.822E-03	2.245E-02	CA2, NR1H4
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	8.783E-03	4.128E-02	PTPN1, PTPRF
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	6.875E-03	3.590E-02	CA2, PLA2G1B

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
NA: NA	Christmas disease	NA	F10;
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	F10;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	F10;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F10;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Blood coagulation disorders	D65-D68	F10;
I00-I99: Diseases of the circulatory system	Prophylaxis of deep vein thrombosis	I80-I82, I80.2	F10;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Renal cancer	C64	F10;
I00-I99: Diseases of the circulatory system	Venous thrombosis	I80-I82	F10;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hemophilia	D66-D68	F10;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hematology	D50-D77	F10;
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	F10;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	Venous thromboembolism	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Deep venous clots	I80.2	F10;
I00-I99: Diseases of the circulatory system	Deep vein thrombosis	I80-I82, I80.2	F10;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	F10;
NA: NA	Haemophilia B	NA	F10;
I00-I99: Diseases of the circulatory system	Thromboembolic disorders	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Coagulation	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	F10;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases