Plant Name: Taxus wallichiana
Taxonomic Information:
Plant ID: NPO23720
Plant Latin Name: Taxus wallichiana
Taxonomy Genus: Taxus
Taxonomy Family: Taxaceae
Plant External Links:
NCBI TaxonomyDB:
147273
Plant-of-the-World-Online:
263869-1
Used in Medicines:
Country/Region:
Pakistan; China; IndiaTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM; HomeopathyGeographical Distribution:
Pakistan; Indonesia; Myanmar; Philippines; Nepal; India; Vietnam; China; Laos
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| OPRD1; TACR2; | |
| ADA; | |
| BCL2; | |
| MTOR; TERT; HSD17B10; USP2; | |
| MAPK1; MERTK; | |
| THRB; | |
| TP53; | |
| SLCO1B3; SLCO1B1; | |
| LMNA; RAB9A; NPC1; TUBB3; PMP22; GMNN; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | MTOR | Serine/threonine-protein kinase mTOR | P42345 | CHEMBL2842 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Hydrolase | ADA | Adenosine deaminase | P00813 | CHEMBL1910 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Nuclear hormone receptor subfamily 1 group A | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
| Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
| Peptide receptor (family A GPCR) | TACR2 | Neurokinin 2 receptor | P21452 | CHEMBL2327 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Kinase | MERTK | Proto-oncogene tyrosine-protein kinase MER | Q12866 | CHEMBL5331 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | TUBB3 | Tubulin beta-3 chain | Q13509 | CHEMBL2597 |
| Unclassified | PMP22 | Peripheral myelin protein 22 | Q01453 | CHEMBL1293298 |
| Unclassified | GMNN | Geminin | O75496 | CHEMBL1293278 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.973E-09 | 3.189E-05 | BCL2, LMNA, MTOR, OPRD1, TERT, TP53 |
| BP | GO:0007610; behavior | GO:0007610; behavior | 5.625E-09 | 3.596E-05 | BCL2, MAPK1, MTOR, NPC1, OPRD1, TACR2, THRB, TP53, USP2 |
| BP | GO:0032501; multicellular organismal process | GO:0014042; positive regulation of neuron maturation | 8.126E-06 | 1.180E-02 | BCL2, MTOR |
| BP | GO:0050896; response to stimulus | GO:0009267; cellular response to starvation | 1.823E-05 | 1.726E-02 | BCL2, MAPK1, MTOR, TP53 |
| CC | GO:0044464; cell part | GO:0005737; cytoplasm | 4.961E-05 | 2.843E-02 | ADA, BCL2, CYP3A4, GMNN, HSD17B10, MAPK1, MERTK, MTOR, OPRD1, SMN1, SMN2, TP53, TUBB3, USP2 |
| MF | GO:0005488; binding | GO:0008134; transcription factor binding | 5.127E-05 | 2.863E-02 | BCL2, GMNN, MAPK1, MTOR, TERT, TP53 |
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 5.820E-05 | 3.091E-02 | BCL2, MAPK1, MTOR, RAB9A, SMN1, SMN2, TERT, TP53, USP2 |
| CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 8.887E-05 | 3.870E-02 | SMN1, SMN2 |
| CC | GO:0032991; macromolecular complex | GO:0032797; SMN complex | 1.049E-04 | 4.115E-02 | SMN1, SMN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | THRB; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MTOR; |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MTOR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperthyroidism | E05 | THRB; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | MTOR; |
| NA: NA | Coronary artery restenosis | NA | MTOR; |
| C00-D49: Neoplasms | Hairy cell leukemia | C91.4 | ADA; |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MTOR; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | MTOR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypothyroidism | E03 | THRB; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Immunodeficiency | D84.9 | ADA; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | THRB; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | MTOR; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MTOR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Organ rejection | D89.8, T86 | MTOR; |
| C00-D49: Neoplasms | Bladder cancer | C67 | MTOR; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MTOR; |
| C00-D49: Neoplasms | Solid tumors | NA | MTOR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MTOR; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Chronic pain | R52.1-R52.2, G89 | ADA; |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Wound healing | T14.0-T14.1 | THRB; |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MTOR; |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR; |
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR; |
| C00-D49: Neoplasms | Advanced kidney cancer | C64 | MTOR; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | ADA; |
| E00-E89: Endocrine, nutritional and metabolic diseases | High cholesterol levels in blood | E78.0 | THRB; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Transplant rejection | D89.8, T86 | MTOR; |
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>> Targets derived from weak experimental activities
