Plant Name: Otholobium pubescens
Taxonomic Information:
Plant ID: NPO23710
Plant Latin Name: Otholobium pubescens
Taxonomy Genus: Otholobium
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
1888379
Plant-of-the-World-Online:
1132339-2
Used in Medicines:
Unknown.
Geographical Distribution:
Bolivia; Peru; Chile
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | XBP1 | X-box-binding protein 1 | P17861 | CHEMBL1741176 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0065007; biological regulation | GO:0042632; cholesterol homeostasis | 3.442E-05 | 3.747E-01 | NPC1, XBP1 |
| BP | GO:0050896; response to stimulus | GO:0009750; response to fructose | 1.242E-03 | 7.310E-01 | XBP1 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 5.958E-04 | 7.310E-01 | NPC1, RAB9A |
| MF | GO:0005488; binding | GO:0005496; steroid binding | 1.330E-02 | 1.000E+00 | NPC1 |
| MF | GO:0005488; binding | GO:0001158; enhancer sequence-specific DNA binding | 1.422E-02 | 1.000E+00 | XBP1 |
| MF | GO:0005488; binding | GO:0001085; RNA polymerase II transcription factor binding | 1.791E-02 | 1.000E+00 | XBP1 |
| MF | GO:0005488; binding | GO:0036094; small molecule binding | 4.369E-02 | 1.000E+00 | NPC1, RAB9A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 2.248E-02 | 3.142E-02 | XBP1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 2.026E-02 | 3.142E-02 | RAB9A |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 1.834E-02 | 3.142E-02 | NPC1 |
| 09120 Genetic Information Processing | 09123 Folding, sorting and degradation | hsa04141 | Protein processing in endoplasmic reticulum | 2.514E-02 | 3.142E-02 | XBP1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 3.820E-02 | 3.820E-02 | XBP1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
