CMAUP Plant Collective Molecular Activities

Plant Name: Jatropha curcas

Taxonomic Information:

Plant ID: NPO23674
Plant Latin Name: Jatropha curcas
Taxonomy Genus: Jatropha
Taxonomy Family: Euphorbiaceae

Plant External Links:

NCBI TaxonomyDB: 180498
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Brazil; Madagascar; Guinea; Rwanda; Swaziland; Laos; Nigeria; Bolivia; Ghana; Zimbabwe; China; Thailand; Tanzania; Philippines; Indonesia; Vietnam; Angola; Mexico; South Africa; India; Malaysia; Senegal; Congo; Kenya

Traditional Medicine System:

Indian Folk; Unani; Siddha; Ayurveda; TCM; Homeopathy

Geographical Distribution:

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	HCAR2;
Enzyme_unclassified	TDP1;
Voltage-gated sodium channel	SCN5A;
Voltage-gated calcium channel	CACNA1C;
Potassium channels	KCNH2;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Potassium channels	KCNH2	HERG	Q12809	CHEMBL240
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Voltage-gated calcium channel	CACNA1C	Voltage-gated L-type calcium channel alpha-1C subunit	Q13936	CHEMBL1940
Voltage-gated sodium channel	SCN5A	Sodium channel protein type V alpha subunit	Q14524	CHEMBL1980

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0086010; membrane depolarization during action potential	7.957E-07	3.465E-03	CACNA1C, KCNH2, SCN5A
BP	GO:0050896; response to stimulus	GO:0043434; response to peptide hormone	4.998E-06	9.895E-03	NFKB1, PPARA, TLR2, TSHR
CC	GO:0044464; cell part	GO:0009986; cell surface	6.905E-05	7.160E-02	KCNH2, SCN5A, TLR2, TSHR
MF	GO:0005215; transporter activity	GO:0005244; voltage-gated ion channel activity	8.644E-05	7.529E-02	CACNA1C, KCNH2, SCN5A
CC	GO:0032991; macromolecular complex	GO:0034703; cation channel complex	1.043E-04	8.410E-02	CACNA1C, KCNH2, SCN5A
MF	GO:0005488; binding	GO:0042805; actinin binding	1.568E-04	1.034E-01	CACNA1C, NFKB1
MF	GO:0060089; molecular transducer activity	GO:0038023; signaling receptor activity	1.806E-04	1.113E-01	HCAR2, KCNH2, PPARA, TLR2, TSHR
MF	Unclassified;	GO:0004872; receptor activity	3.214E-04	1.428E-01	HCAR2, KCNH2, PPARA, TLR2, TSHR
MF	GO:0005215; transporter activity	GO:0005261; cation channel activity	3.355E-04	1.446E-01	CACNA1C, KCNH2, SCN5A
CC	GO:0016020; membrane	GO:0005886; plasma membrane	7.351E-04	1.878E-01	CACNA1C, HCAR2, KCNH2, SCN5A, TDP1, TLR2, TSHR
CC	GO:0044422; organelle part	GO:0030018; Z disc	1.361E-03	2.254E-01	CACNA1C, SCN5A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.131E-08	9.843E-07	HCAR2, CACNA1C, PPARA, NFKB1, TSHR
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	2.640E-04	8.096E-03	NFKB1, TLR2
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	3.690E-04	8.096E-03	NFKB1, TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	4.653E-04	8.096E-03	NFKB1, TLR2
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	4.279E-04	8.096E-03	PPARA, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05146	Amoebiasis	8.709E-04	9.989E-03	NFKB1, TLR2
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	9.777E-04	9.989E-03	NFKB1, TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	9.414E-04	9.989E-03	NFKB1, TLR2
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.033E-03	9.989E-03	PPARA, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	1.209E-03	1.052E-02	NFKB1, TLR2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases