CMAUP Plant Collective Molecular Activities

Plant Name: Cynanchum viminale

Taxonomic Information:

Plant ID: NPO23639
Plant Latin Name: Cynanchum viminale
Taxonomy Genus: Cynanchum
Taxonomy Family: Apocynaceae

Plant External Links:

NCBI TaxonomyDB: 126774
Plant-of-the-World-Online: 77120427-1

Used in Medicines:

Country/Region:

Madagascar; Angola; South Africa; Tanzania; Zimbabwe; Rwanda; Swaziland; Kenya; Burkina Faso

Traditional Medicine System:

Geographical Distribution:

Madagascar; Sudan; Ethiopia; Rwanda; Somalia; Swaziland; Nigeria; Malawi; Benin; Ghana; Saudi Arabia; Australia; Burkina Faso; Zimbabwe; Thailand; Tanzania; Eritrea; Oman; Philippines; Sri Lanka; Namibia; Mali; Yemen; Pakistan; Seychelles; Angola; Myanmar; Equatorial Guinea; South Africa; India; Lesotho; Djibouti; Uganda; Burundi; Kenya; Botswana

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	RECQL; BLM; ALOX15; HSD17B10;
Protein Kinase	PIM1; MAPK1; CSNK2A1;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Serine protease	ELANE;
Transcription Factor	HIF1A;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Serine protease	ELANE	Leukocyte elastase	P08246	CHEMBL248
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	3.342E-06	1.399E-02	CSNK2A1, ELANE, ESR1, HIF1A, MAPK1, PIM1, TSHR
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	6.433E-07	1.399E-02	ESR1, ESR2
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	2.279E-06	1.399E-02	CSNK2A1, HIF1A, MAPT
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	3.856E-06	1.399E-02	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.856E-06	1.399E-02	CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0009378; four-way junction helicase activity	6.423E-06	1.748E-02	BLM, RECQL
BP	GO:0040007; growth	GO:0040008; regulation of growth	8.819E-06	2.097E-02	CSNK2A1, ELANE, ESR2, HIF1A, MAPT, PIM1
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.631E-06	2.097E-02	CYP2C9, CYP3A4
BP	GO:0009987; cellular process	GO:0019896; axonal transport of mitochondrion	2.308E-05	2.513E-02	HIF1A, MAPT
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	2.308E-05	2.513E-02	BLM, RECQL
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	2.163E-05	2.513E-02	HIF1A, MAPK1, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.516E-06	1.773E-04	CYP2C9, ALOX15, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	2.422E-05	1.417E-03	MAPK1, ESR1, ESR2
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	6.287E-05	2.452E-03	MAPK1, ESR1, ESR2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	9.078E-05	2.480E-03	CYP2C9, ALOX15, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.060E-04	2.480E-03	MAPK1, ESR1, HIF1A
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	5.234E-04	8.748E-03	MAPK1, HIF1A, ESR1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	3.008E-04	5.866E-03	MAPK1, MAPT, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	9.334E-04	1.140E-02	PIM1, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	1.034E-03	1.140E-02	MAPK1, HIF1A
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	1.249E-03	1.140E-02	MAPK1, HIF1A

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases