Plant Name: Hedera rhombea
Taxonomic Information:
Plant ID: NPO23598
Plant Latin Name: Hedera rhombea
Taxonomy Genus: Hedera
Taxonomy Family: Araliaceae
Plant External Links:
NCBI TaxonomyDB:
85360
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
South Korea; ChinaTraditional Medicine System:
TCMGeographical Distribution:
South Korea; China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| AR; NR3C2; PGR; NR3C1; | |
| NR1H4; | |
| NR1I2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Nuclear hormone receptor subfamily 1 group I | NR1I2 | Pregnane X receptor | O75469 | CHEMBL3401 |
| Nuclear hormone receptor subfamily 3 group C | AR | Androgen Receptor | P10275 | CHEMBL1871 |
| Nuclear hormone receptor subfamily 3 group C | NR3C2 | Mineralocorticoid receptor | P08235 | CHEMBL1994 |
| Nuclear hormone receptor subfamily 3 group C | PGR | Progesterone receptor | P06401 | CHEMBL208 |
| Nuclear hormone receptor subfamily 3 group C | NR3C1 | Glucocorticoid receptor | P04150 | CHEMBL2034 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 2.940E-13 | 2.078E-09 | AR, NR1H4, NR1I2, NR3C1, NR3C2, PGR |
| MF | GO:0005488; binding | GO:0005496; steroid binding | 9.297E-12 | 3.374E-08 | AR, NR1H4, NR3C1, NR3C2, PGR |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 5.460E-10 | 1.321E-06 | AR, NR1H4, NR1I2, PGR |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 5.462E-09 | 1.189E-05 | AR, NR1H4, NR1I2, NR3C1, NR3C2, PGR |
| MF | GO:0005488; binding | GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding | 2.105E-07 | 2.696E-04 | AR, NR1H4, NR1I2, NR3C1, PGR |
| BP | GO:0022414; reproductive process | GO:0060748; tertiary branching involved in mammary gland duct morphogenesis | 2.412E-07 | 2.918E-04 | AR, PGR |
| MF | Unclassified; | GO:0004872; receptor activity | 2.698E-07 | 3.092E-04 | AR, NR1H4, NR1I2, NR3C1, NR3C2, PGR |
| MF | GO:0140110; transcription regulator activity | GO:0001077; transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | 5.727E-07 | 4.618E-04 | AR, NR1H4, NR3C1, PGR |
| BP | GO:0009987; cellular process | GO:0030518; intracellular steroid hormone receptor signaling pathway | 1.256E-06 | 8.821E-04 | AR, NR3C1, PGR |
| BP | GO:0008152; metabolic process | GO:0045944; positive regulation of transcription from RNA polymerase II promoter | 3.395E-06 | 2.240E-03 | AR, NR1H4, NR1I2, NR3C1, PGR |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 6.251E-16 | 1.361E-11 | AR, NR1H4, NR1I2, NR3C1, NR3C2, PGR |
| CC | GO:0043226; organelle | GO:0016607; nuclear speck | 5.189E-03 | 4.955E-01 | AR, NR3C1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04114 | Oocyte meiosis | 5.537E-04 | 3.876E-03 | AR, PGR |
| 09150 Organismal Systems | 09155 Excretory system | hsa04960 | Aldosterone-regulated sodium reabsorption | 1.164E-02 | 4.066E-02 | NR3C2 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 2.641E-02 | 4.066E-02 | AR |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.111E-02 | 4.066E-02 | NR1H4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04914 | Progesterone-mediated oocyte maturation | 2.905E-02 | 4.066E-02 | PGR |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 8.028E-02 | 9.367E-02 | NR3C1 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.134E-01 | 1.134E-01 | AR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | NR1I2; |
| C00-D49: Neoplasms | Female androgenresponsive recurrent mammary cancer | C50 | AR; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Muscle atrophy | M62.5 | AR; |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | PGR; |
| C00-D49: Neoplasms | Endometrial cancer | C54.1 | PGR; |
| C00-D49: Neoplasms | Uterine leiomyoma | D25 | PGR; |
| C00-D49: Neoplasms | Uterine fibroids | D25 | PGR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Estrogen deficiency | E28.39 | PGR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Cystic fibrosis | E84 | AR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | AR; |
| C00-D49: Neoplasms | Metastatic prostate cancer | C61 | AR; |
| Z00-Z99: Factors influencing health status and contact with health services | Contraception | Z30 | AR; PGR; |
| N00-N99: Diseases of the genitourinary system | Prostate hyperplasia | N40 | AR; |
| C00-D49: Neoplasms | Hormone refractory prostate cancer | C61 | AR; |
| O00-O9A: Pregnancy, childbirth and the puerperium | Premature labour | O60.1, P07.3 | PGR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Endocrine disease | E00-E35 | AR; |
| C00-D49: Neoplasms | Prostate cancer | C61 | AR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypogonadism | E23.0, E28.3, E29.1 | AR; |
| Z00-Z99: Factors influencing health status and contact with health services | Female contraception | Z30 | PGR; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | AR; |
| N00-N99: Diseases of the genitourinary system | Menstrual disorders | N91-N95 | PGR; |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | AR; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis in post-menopausal women | M80-M81 | AR; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | AR; PGR; |
| NA: NA | Male hypogonadism | NA | AR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Male hormonal deficiencies | E20-E35 | AR; |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | AR; |
| N00-N99: Diseases of the genitourinary system | Gynecological disorder | N70-N98 | PGR; |
| C00-D49: Neoplasms | Breast cancer | C50 | AR; |
| C00-D49: Neoplasms | Advanced breast carcinoma | NA | PGR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Testosterone deficiency | E29.1 | AR; |
| C00-D49: Neoplasms | Bladder cancer | C67 | AR; |
| C00-D49: Neoplasms | Advanced prostate cancer | C61 | AR; |
| C00-D49: Neoplasms | Advanced endometrium carcinoma | NA | PGR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatological disease | L00-L99 | AR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | AR; |
| C00-D49: Neoplasms | Castration-resistant prostate cancer | C61 | AR; |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | AR; |
| K00-K95: Diseases of the digestive system | Alcoholic hepatitis | K70.1 | AR; |
| Z00-Z99: Factors influencing health status and contact with health services | Hormonal contraceptives | Z30 | PGR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | AR; PGR; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cachexia | R64 | AR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Alopecia | L65.9 | AR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
