Plant Name: Vicia faba
Taxonomic Information:
Plant ID: NPO23510
Plant Latin Name: Vicia faba
Taxonomy Genus: Vicia
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
3906
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Turkey; Italy; India; Jordan; Chile; China; ArgentinaTraditional Medicine System:
Indian Folk; TCM; SiddhaGeographical Distribution:
Turkey; Italy; India; Jordan; Chile; China; Argentina
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| SENP6; SENP7; SENP8; | |
| CASP3; | |
| ABCG2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cysteine protease | CASP3 | Caspase-3 | P42574 | CHEMBL2334 |
| Enzyme_unclassified | SENP6 | Sentrin-specific protease 6 | Q9GZR1 | CHEMBL1741215 |
| Enzyme_unclassified | SENP7 | Sentrin-specific protease 7 | Q9BQF6 | CHEMBL1741213 |
| Enzyme_unclassified | SENP8 | Sentrin-specific protease 8 | Q96LD8 | CHEMBL1741207 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0008234; cysteine-type peptidase activity | 5.313E-08 | 1.157E-03 | CASP3, SENP6, SENP7, SENP8 |
| BP | GO:0008152; metabolic process | GO:0016926; protein desumoylation | 1.125E-06 | 1.225E-02 | SENP6, SENP8 |
| BP | GO:0008152; metabolic process | GO:0006508; proteolysis | 8.279E-05 | 3.005E-01 | CASP3, SENP6, SENP7, SENP8 |
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 2.105E-02 | 1.000E+00 | CASP3 |
| BP | GO:0050896; response to stimulus | GO:0060359; response to ammonium ion | 2.257E-02 | 1.000E+00 | CASP3 |
| BP | GO:0009987; cellular process | GO:0097191; extrinsic apoptotic signaling pathway | 2.308E-02 | 1.000E+00 | CASP3 |
| BP | GO:0050896; response to stimulus | GO:0043279; response to alkaloid | 2.334E-02 | 1.000E+00 | CASP3 |
| CC | GO:0043226; organelle | GO:0005634; nucleus | 1.989E-02 | 1.000E+00 | ABCG2, CASP3, SENP7, SENP8 |
| MF | GO:0005215; transporter activity | GO:0008559; xenobiotic transmembrane transporting ATPase activity | 1.811E-03 | 1.000E+00 | ABCG2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09131 Membrane transport | hsa02010 | ABC transporters | 1.095E-02 | 5.480E-02 | ABCG2 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 1.269E-02 | 5.480E-02 | CASP3 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.368E-02 | 5.480E-02 | CASP3 |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 1.541E-02 | 5.480E-02 | CASP3 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05416 | Viral myocarditis | 1.466E-02 | 5.480E-02 | CASP3 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.689E-02 | 5.480E-02 | CASP3 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 2.769E-02 | 5.480E-02 | CASP3 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 3.597E-02 | 5.480E-02 | CASP3 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 3.719E-02 | 5.480E-02 | CASP3 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05012 | Parkinson's disease | 3.500E-02 | 5.480E-02 | CASP3 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
