Plant Name: Fissistigma balansae
Taxonomic Information:
Plant ID: NPO23507
Plant Latin Name: Fissistigma balansae
Taxonomy Genus: Fissistigma
Taxonomy Family: Annonaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Protein Kinase | CDK2 | Cyclin-dependent kinase 2 | P24941 | CHEMBL301 |
| Protein Kinase | AURKA | Serine/threonine-protein kinase Aurora-A | O14965 | CHEMBL4722 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | CDK4 | Cyclin-dependent kinase 4 | P11802 | CHEMBL331 |
| Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0030332; cyclin binding | 3.735E-08 | 5.552E-05 | CDK1, CDK2, CDK4 |
| MF | GO:0003824; catalytic activity | GO:0004693; cyclin-dependent protein serine/threonine kinase activity | 5.436E-08 | 6.230E-05 | CDK1, CDK2, CDK4 |
| CC | GO:0044464; cell part | GO:0000307; cyclin-dependent protein kinase holoenzyme complex | 8.850E-08 | 8.379E-05 | CDK1, CDK2, CDK4 |
| CC | GO:0043226; organelle | GO:0005876; spindle microtubule | 1.943E-07 | 1.365E-04 | AURKA, AURKB, CDK1 |
| BP | GO:0009987; cellular process | GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 3.135E-07 | 1.838E-04 | AURKA, CDK1, CDK2 |
| CC | GO:0032991; macromolecular complex | GO:0032133; chromosome passenger complex | 5.359E-07 | 2.737E-04 | AURKA, AURKB |
| BP | GO:0032502; developmental process | GO:0031100; animal organ regeneration | 5.820E-07 | 2.755E-04 | AURKA, CDK1, CDK4 |
| BP | GO:0008152; metabolic process | GO:0031145; anaphase-promoting complex-dependent catabolic process | 6.800E-07 | 3.085E-04 | AURKA, AURKB, CDK1 |
| MF | GO:0003824; catalytic activity | GO:0035174; histone serine kinase activity | 8.038E-07 | 3.295E-04 | AURKA, AURKB |
| BP | GO:0009987; cellular process | GO:0010972; negative regulation of G2/M transition of mitotic cell cycle | 1.108E-06 | 4.234E-04 | AURKA, AURKB, CDK1 |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 2.598E-06 | 8.702E-04 | AURKA, AURKB, CDK1, CDK2, CDK4 |
| BP | GO:0008152; metabolic process | GO:0035404; histone-serine phosphorylation | 3.534E-06 | 1.026E-03 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0000780; condensed nuclear chromosome, centromeric region | 3.534E-06 | 1.026E-03 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0031616; spindle pole centrosome | 3.534E-06 | 1.026E-03 | AURKA, AURKB |
| BP | GO:0009987; cellular process | GO:0045931; positive regulation of mitotic cell cycle | 4.014E-06 | 1.120E-03 | AURKA, CDK1, CDK4 |
| BP | GO:0051179; localization | GO:0034501; protein localization to kinetochore | 4.177E-06 | 1.139E-03 | AURKB, CDK1 |
| BP | GO:0009987; cellular process | GO:1901796; regulation of signal transduction by p53 class mediator | 7.338E-06 | 1.858E-03 | AURKA, AURKB, CDK2 |
| BP | GO:0008152; metabolic process | GO:0051054; positive regulation of DNA metabolic process | 1.301E-05 | 2.920E-03 | AURKB, CDK1, CDK2 |
| CC | GO:0043226; organelle | GO:0051233; spindle midzone | 2.485E-05 | 5.203E-03 | AURKA, AURKB |
| BP | GO:0009987; cellular process | GO:0035690; cellular response to drug | 3.013E-05 | 6.074E-03 | CDK1, CDK2, CDK4 |
| BP | GO:0009987; cellular process | GO:0000226; microtubule cytoskeleton organization | 3.959E-05 | 7.629E-03 | AURKA, AURKB, CDK1 |
| MF | GO:0003824; catalytic activity | GO:0004712; protein serine/threonine/tyrosine kinase activity | 4.596E-05 | 8.703E-03 | AURKA, AURKB |
| BP | GO:0009987; cellular process | GO:0051716; cellular response to stimulus | 4.718E-05 | 8.856E-03 | AURKA, AURKB, CDK1, CDK2, CDK4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04115 | p53 signaling pathway | 3.911E-07 | 9.777E-06 | CDK4, CDK2, CDK1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04114 | Oocyte meiosis | 2.250E-06 | 1.921E-05 | CDK2, CDK1, AURKA |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 1.045E-05 | 6.533E-05 | CDK4, CDK2, CDK1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04110 | Cell cycle | 2.305E-06 | 1.921E-05 | CDK4, CDK2, CDK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 1.812E-04 | 9.061E-04 | CDK4, CDK2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04914 | Progesterone-mediated oocyte maturation | 2.354E-04 | 9.808E-04 | CDK2, CDK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 5.217E-04 | 1.630E-03 | CDK4, CDK2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 4.529E-04 | 1.618E-03 | CDK4, CDK2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05169 | Epstein-Barr virus infection | 9.949E-04 | 2.487E-03 | CDK2, CDK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05168 | Herpes simplex infection | 8.356E-04 | 2.321E-03 | CDK2, CDK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 2.802E-03 | 6.367E-03 | CDK4, CDK2 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 3.778E-03 | 7.870E-03 | CDK4, CDK2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CDK2; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | CDK2; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | CDK1; |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | CDK2; |
| C00-D49: Neoplasms | Breast cancer | C50 | CDK1; |
| C00-D49: Neoplasms | Thymoma | C37, D15.0 | CDK2; |
| C00-D49: Neoplasms | Cancer | C00-C96 | CDK2; CDK1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
