CMAUP Plant Collective Molecular Activities

Plant Name: Fibraurea recisa

Taxonomic Information:

Plant ID: NPO2341
Plant Latin Name: Fibraurea recisa
Taxonomy Genus: Fibraurea
Taxonomy Family: Menispermaceae

Plant External Links:

NCBI TaxonomyDB: 714469
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD5; HTR1A; DRD3; DRD1; DRD2;
Hydrolase	ACHE;
Unclassified	F3; SIGMAR1; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Small molecule receptor (family A GPCR)	DRD5	Dopamine D5 receptor	P21918	CHEMBL1850
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	SIGMAR1	Sigma opioid receptor	Q99720	CHEMBL287
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0035240; dopamine binding	2.584E-11	1.875E-07	DRD1, DRD2, DRD3, DRD5
BP	GO:0050896; response to stimulus	GO:0001975; response to amphetamine	5.385E-10	1.954E-06	DRD1, DRD2, DRD3, DRD5
BP	GO:0023052; signaling	GO:0051584; regulation of dopamine uptake involved in synaptic transmission	5.588E-09	1.014E-05	DRD1, DRD2, DRD3
BP	GO:0009987; cellular process	GO:0007191; adenylate cyclase-activating dopamine receptor signaling pathway	1.197E-08	1.861E-05	DRD1, DRD3, DRD5
BP	GO:0050896; response to stimulus	GO:0060134; prepulse inhibition	2.850E-08	3.266E-05	DRD1, DRD2, DRD3
BP	GO:0009987; cellular process	GO:0060158; phospholipase C-activating dopamine receptor signaling pathway	2.850E-08	3.266E-05	DRD1, DRD2, DRD5
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	1.134E-07	8.513E-05	DRD1, DRD2, DRD3
BP	GO:0007610; behavior	GO:0046960; sensitization	2.412E-07	1.545E-04	DRD1, DRD5
CC	GO:0043226; organelle	GO:0097730; non-motile cilium	4.917E-07	2.433E-04	DRD1, DRD2, DRD5
BP	GO:0009987; cellular process	GO:0060160; negative regulation of dopamine receptor signaling pathway	7.235E-07	3.352E-04	DRD2, DRD3
BP	GO:0065007; biological regulation	GO:0045776; negative regulation of blood pressure	1.135E-06	5.044E-04	DRD2, DRD3, DRD5
MF	GO:0060089; molecular transducer activity	GO:0001588; dopamine neurotransmitter receptor activity, coupled via Gs	1.447E-06	5.833E-04	DRD1, DRD5
BP	GO:0007610; behavior	GO:0008542; visual learning	1.707E-06	6.638E-04	DRD1, DRD2, DRD3
MF	Unclassified;	GO:0004872; receptor activity	2.088E-06	7.978E-04	DRD1, DRD2, DRD3, DRD5, F3, HTR1A, SIGMAR1
BP	Unclassified;	GO:0021853; cerebral cortex GABAergic interneuron migration	2.410E-06	8.604E-04	DRD1, DRD2
BP	GO:0040011; locomotion	GO:0090325; regulation of locomotion involved in locomotory behavior	2.410E-06	8.604E-04	DRD2, DRD3
BP	GO:0032501; multicellular organismal process	GO:0007416; synapse assembly	5.371E-06	1.462E-03	ACHE, DRD1, DRD2
MF	GO:0060089; molecular transducer activity	GO:0001591; dopamine neurotransmitter receptor activity, coupled via Gi/Go	6.743E-06	1.807E-03	DRD2, DRD3
CC	GO:0044422; organelle part	GO:0060170; ciliary membrane	8.983E-06	2.301E-03	DRD1, DRD2, DRD5
BP	GO:0009987; cellular process	GO:0007195; adenylate cyclase-inhibiting dopamine receptor signaling pathway	1.083E-05	2.568E-03	DRD2, DRD3
BP	GO:0032501; multicellular organismal process	GO:0030432; peristalsis	1.083E-05	2.568E-03	DRD1, DRD2
BP	GO:0050896; response to stimulus	GO:0034776; response to histamine	1.323E-05	2.941E-03	DRD2, DRD3
BP	GO:0009987; cellular process	GO:0002031; G-protein coupled receptor internalization	1.323E-05	2.941E-03	DRD2, DRD3
BP	GO:0032502; developmental process	GO:0021756; striatum development	1.323E-05	2.941E-03	DRD1, DRD2
BP	GO:0007610; behavior	GO:0007625; grooming behavior	1.588E-05	3.357E-03	DRD1, DRD2
BP	GO:0032501; multicellular organismal process	GO:0035815; positive regulation of renal sodium excretion	1.876E-05	3.928E-03	DRD2, DRD3
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	2.423E-05	5.026E-03	DRD1, DRD2, DRD3, DRD5, HTR1A, SIGMAR1
BP	GO:0065007; biological regulation	GO:0006874; cellular calcium ion homeostasis	2.848E-05	5.796E-03	DRD1, DRD2, DRD3, DRD5
BP	GO:0023052; signaling	GO:0060292; long term synaptic depression	2.884E-05	5.814E-03	DRD1, DRD5
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	2.998E-05	5.935E-03	DRD1, DRD5, HTR1A
BP	GO:0009987; cellular process	GO:0019226; transmission of nerve impulse	3.675E-05	6.822E-03	DRD1, DRD5
BP	GO:0008152; metabolic process	GO:0042053; regulation of dopamine metabolic process	4.106E-05	7.210E-03	DRD1, HTR1A
BP	GO:0032501; multicellular organismal process	GO:0045187; regulation of circadian sleep/wake cycle, sleep	4.106E-05	7.210E-03	DRD2, DRD3
BP	GO:0007610; behavior	GO:0007617; mating behavior	4.106E-05	7.210E-03	DRD1, DRD5
BP	GO:0051179; localization	GO:0050482; arachidonic acid secretion	6.068E-05	9.787E-03	DRD2, DRD3

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.170E-07	2.692E-06	HTR1A, DRD1, DRD2, DRD3, DRD5
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	3.366E-07	3.871E-06	DRD1, DRD2, DRD3, DRD5
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.906E-06	1.461E-05	HTR1A, DRD1, DRD2, DRD5
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	2.613E-04	1.503E-03	DRD1, DRD2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	8.418E-04	3.872E-03	DRD1, DRD2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.358E-03	5.207E-03	CYP2D6, HTR1A
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05012	Parkinson's disease	2.170E-03	7.130E-03	DRD1, DRD2
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	3.457E-03	8.834E-03	DRD1, DRD5
09160 Human Diseases	09164 Substance dependence	hsa05034	Alcoholism	3.419E-03	8.834E-03	DRD1, DRD2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Benign prostatic hypertrophy	NA	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6; HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	DRD2;
J00-J99: Diseases of the respiratory system	Asthma	J45	DRD2;
NA: NA	False perceptions	NA	DRD2;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	DRD2;
NA: NA	Corneal vascularity	NA	DRD2;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; DRD2; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE; DRD2; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	DRD2;
NA: NA	Hyperaemia	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3; HTR1A;
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	DRD2;
NA: NA	Peripheral sensory neuropathies	NA	HTR1A;
NA: NA	Peripheral vasoconstriction	NA	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;
O00-O9A: Pregnancy, childbirth and the puerperium	Postpartum haemorrhage	O72	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD2; DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Advanced stage Parkinson's disease	F02.3, G20	DRD2;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	DRD2;
I00-I99: Diseases of the circulatory system	Hypotension	I95	DRD2;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
NA: NA	Bulimia nervosa	NA	HTR1A;
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Carcinoid syndrome	E34.0	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A;
C00-D49: Neoplasms	Solid tumours	C00-D48	DRD5;
NA: NA	Social phobia	NA	HTR1A;
I00-I99: Diseases of the circulatory system	Cardiotonic	I50	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR1A;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	DRD2;
NA: NA	Episode	NA	HTR1A;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD5; DRD1; DRD2; DRD3; HTR1A;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Breast cancer	C50	DRD2;
NA: NA	Schizoaffective disorder	NA	HTR1A;
NA: NA	Anxiety disorders	NA	HTR1A;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	DRD2;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE; DRD1; DRD2; HTR1A;
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; DRD1; DRD2; HTR1A;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1; DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; DRD1; HTR1A;
I00-I99: Diseases of the circulatory system	Pulmonary hypertension	I27.0, I27.2	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1; HTR1A;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
H00-H59: Diseases of the eye and adnexa	Ophthalmic disease	H00-H59	DRD2;
NA: NA	Cervical dystonia	NA	HTR1A;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychosis	F20-F29	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; DRD2; DRD3; HTR1A;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
NA: NA	Itching	NA	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	DRD2;
NA: NA	Inflammatory diseases	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6; DRD2;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	HTR1A;
NA: NA	Upper abdominal bloating	NA	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Depressive fatigue	R53.82	DRD2;
K00-K95: Diseases of the digestive system	Dermal necrosis	K05	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
NA: NA	Schizoaffective disorders	NA	DRD2;
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A;
NA: NA	Vomiting	NA	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR1A;
K00-K95: Diseases of the digestive system	Gastrointestinal problems	K30-K31, Q40-Q41	DRD2;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
NA: NA	Malignant phaeochromocytoma	NA	DRD2;
NA: NA	Malignant essential hypertension	NA	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	DRD2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; DRD2;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
I00-I99: Diseases of the circulatory system	Maintain blood pressure in hypotensive states	I10	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	DRD2; HTR1A;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1; DRD2; HTR1A;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases