CMAUP Plant Collective Molecular Activities

Plant Name: Hypericum reptans

Taxonomic Information:

Plant ID: NPO23375
Plant Latin Name: Hypericum reptans
Taxonomy Genus: Hypericum
Taxonomy Family: Hypericaceae

Plant External Links:

NCBI TaxonomyDB: 673933
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA2; CA7; CA4; CA14;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Enzyme_unclassified	ALOX15; CBR1;
Oxidoreductase	XDH;
Unclassified	FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005506; iron ion binding	7.665E-12	5.563E-08	ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.616E-11	1.446E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.075E-10	2.602E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.346E-10	5.108E-07	CA14, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.026E-09	1.718E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.517E-09	2.359E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.305E-08	2.390E-05	CA14, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0020037; heme binding	2.254E-08	2.390E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	4.950E-08	4.686E-05	ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	5.322E-07	3.996E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.463E-06	8.609E-04	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.790E-06	9.743E-04	CYP19A1, CYP1A1, CYP2C19
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.134E-06	1.106E-03	CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.924E-06	1.447E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	7.305E-06	3.359E-03	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.363E-05	5.817E-03	CYP1A1, CYP1A2
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	2.188E-05	8.989E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	2.444E-05	9.853E-03	CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.991E-09	2.887E-08	CBR1, CYP1A2, CYP1A1, CYP1B1, CYP2C19
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.556E-10	1.031E-08	CA2, CA4, CA7, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6.236E-08	6.028E-07	CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.590E-07	1.153E-06	CBR1, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.657E-06	1.284E-05	CYP1A2, CYP1A1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	8.033E-06	2.588E-05	CBR1, CYP1A2, ALOX15, CYP1A1, CYP2C19, CYP19A1, XDH
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	5.249E-06	1.903E-05	CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	9.870E-07	5.725E-06	CYP1A2, ALOX15, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.008E-05	2.923E-05	CBR1, ALOX15, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.229E-04	2.153E-03	CYP1A2, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.039E-03	2.153E-03	CYP1A2, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.707E-03	5.233E-03	ALOX15, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.039E-03	2.153E-03	FABP5, PPARA
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.142E-04	3.010E-04	CA2, CA4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.545E-06	1.883E-05	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
I00-I99: Diseases of the circulatory system	Heart failure	I50	XDH;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
NA: NA	Edema	NA	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	XDH;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH;
J00-J99: Diseases of the respiratory system	Asthma	J45	CBR1;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases