CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Peptide receptor (family A GPCR)	NPSR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF;
Enzyme_unclassified	RECQL; HSD11B1; AKR1B10;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Unclassified	HTT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521

Showing 1 to 10 of 13 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	4.480E-07	5.500E-03	ACP1, PTPN1, PTPN2, PTPRF
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.254E-06	6.826E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	2.507E-06	1.092E-02	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	4.310E-06	1.519E-02	NR1H4, PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:1903897; regulation of PERK-mediated unfolded protein response	1.876E-05	3.713E-02	PTPN1, PTPN2
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.254E-06	6.826E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	1.168E-05	2.544E-02	ACP1, PTPN2

Showing 1 to 7 of 7 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.933E-02	6.947E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2.316E-02	6.947E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2.061E-02	6.947E-02	AKR1B10
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.354E-05	2.844E-04	PTPN1, ACP1, PTPRF
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	3.557E-03	2.490E-02	PTPN1, PTPRF
09150 Organismal Systems	09159 Environmental adaptation	hsa04710	Circadian rhythm	1.933E-02	6.947E-02	RORC
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	2.207E-03	2.318E-02	PTPN1, PTPRF
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	4.706E-02	7.370E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	5.264E-02	7.370E-02	LMNA
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.202E-02	7.370E-02	HSD11B1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1;

Showing 1 to 10 of 11 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Hertia intermedia

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities