CMAUP Plant Collective Molecular Activities

Plant Name: Heracleum sphondylium

Taxonomic Information:

Plant ID: NPO23289
Plant Latin Name: Heracleum sphondylium
Taxonomy Genus: Heracleum
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 40919
Plant-of-the-World-Online: 843179-1

Used in Medicines:

Country/Region:

Albania; China; Finland; Bulgaria

Traditional Medicine System:

TCM

Medicinal Functions:

Antidiarrhoeal; Antipsoriatic; Aphrodisiac; Digestive; Expectorant; Sedative

Geographical Distribution:

Turkey; Italy; France; Ireland; Norway; China; Belgium; Germany; Haiti; Spain; Netherlands; Denmark; Poland; Finland; Morocco; New Zealand; Russia; Bulgaria; Romania; Albania; Portugal; United Kingdom; Austria; Greece; Hungary

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF; CDC25B;
Enzyme_unclassified	ALPL; RECQL; PLA2G1B; HSD11B1; AKR1B10; HSD17B10; POLB;
Hydrolase	GAA;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP3A4; CYP1A2; CYP2A6; CYP2A13; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.744E-11	5.976E-07	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	3.934E-10	2.807E-06	AKR1B10, CYP1A2, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD11B1, NR1H4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.157E-10	2.807E-06	CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	9.011E-10	3.924E-06	CYP1A2, CYP2A6, CYP2C19, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.244E-09	6.980E-06	CYP1A2, CYP2A13, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	4.567E-09	9.945E-06	CYP1A2, CYP2A13, CYP2C19, CYP2D6, CYP3A4, RORC
MF	GO:0005488; binding	GO:0020037; heme binding	9.185E-09	1.667E-05	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.081E-08	1.811E-05	CYP1A2, CYP2A13, CYP2A6, CYP2C19
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.597E-08	2.319E-05	CYP1A2, CYP2A13, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.498E-08	4.232E-05	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	5.879E-08	5.566E-05	CYP2A13, CYP2A6, CYP2D6
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.257E-07	1.013E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	3.681E-07	2.290E-04	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	1.133E-06	6.168E-04	CYP2A13, CYP2A6, CYP2C19
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	1.480E-06	7.492E-04	CYP2A13, CYP2A6
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	4.435E-06	1.876E-03	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.435E-06	1.876E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	4.435E-06	1.876E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	8.864E-06	3.447E-03	PTPN1, PTPN2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	8.864E-06	3.447E-03	CYP1A2, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	9.280E-05	2.768E-02	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD11B1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.449E-10	3.282E-08	HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.003E-10	3.352E-08	HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.704E-08	7.609E-07	CYP2A6, CYP2D6, CYP1A2, CYP3A4, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	7.071E-07	1.895E-05	HSD11B1, CYP2A6, AKR1B10, PLA2G1B, GAA, CYP1A2, ALPL, CYP2C19, CYP3A4, HSD17B10
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.712E-08	1.243E-06	PLA2G1B, CYP1A2, CYP3A4, CYP2C19
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.735E-06	3.874E-05	PTPN1, MAPK1, ACP1, PTPRF
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6.316E-05	9.403E-04	CYP2A6, CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4.486E-05	7.514E-04	HSD11B1, CYP1A2, CYP3A4
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	2.932E-04	3.869E-03	PTPN1, NFKB1, PTPRF
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.176E-04	3.869E-03	CYP2D6, MAPK1, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	5.975E-04	6.158E-03	PTPN1, MAPK1, PTPRF
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.881E-04	6.158E-03	AKR1B10, GAA
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.377E-05	2.636E-04	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; CDC25B;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases