Plant Name: Neolitsea daibuensis
Taxonomic Information:
Plant ID: NPO23270
Plant Latin Name: Neolitsea daibuensis
Taxonomy Genus: Neolitsea
Taxonomy Family: Lauraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TAS2R31; | |
| TSHR; | |
| FAAH; TERT; | |
| PPARA; PPARD; PPARG; | |
| ALDH2; | |
| FABP5; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | FAAH | Anandamide amidohydrolase | O00519 | CHEMBL2243 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Oxidoreductase | ALDH2 | Aldehyde dehydrogenase | P05091 | CHEMBL1935 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Taste receptor (taste family GPCR) | TAS2R31 | Taste receptor type 2 member 31 | P59538 | CHEMBL2034804 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0009755; hormone-mediated signaling pathway | 6.566E-07 | 4.766E-03 | PPARA, PPARD, PPARG, TSHR |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.275E-06 | 5.552E-03 | PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 1.928E-06 | 6.534E-03 | PPARA, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 2.892E-06 | 6.534E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 2.892E-06 | 6.534E-03 | PPARA, PPARG |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 3.301E-06 | 6.534E-03 | PPARA, PPARD, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 2.244E-06 | 6.534E-03 | PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:0006631; fatty acid metabolic process | 6.409E-06 | 1.073E-02 | FAAH, PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 1.059E-05 | 1.537E-02 | PPARA, PPARD |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 1.059E-05 | 1.537E-02 | PPARD, PPARG |
| MF | GO:0005488; binding | GO:0001223; transcription coactivator binding | 3.651E-05 | 2.564E-02 | PPARA, TERT |
| MF | GO:0005488; binding | GO:0008134; transcription factor binding | 9.606E-05 | 4.613E-02 | PPARA, PPARD, PPARG, TERT |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 6.738E-03 | 5.419E-01 | FABP5, PPARA, PPARD, PPARG, TERT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.613E-08 | 5.808E-07 | FABP5, PPARG, PPARA, PPARD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 3.387E-03 | 5.249E-02 | PPARA, TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.290E-02 | 5.249E-02 | PPARG, PPARD |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00340 | Histidine metabolism | 1.075E-02 | 5.249E-02 | ALDH2 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00053 | Ascorbate and aldarate metabolism | 1.209E-02 | 5.249E-02 | ALDH2 |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 1.298E-02 | 5.249E-02 | PPARG |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 2.536E-02 | 5.249E-02 | PPARD |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 2.492E-02 | 5.249E-02 | TSHR |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 2.360E-02 | 5.249E-02 | TSHR |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 2.624E-02 | 5.249E-02 | ALDH2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | ALDH2; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Substance dependence | F10-F19 | ALDH2; |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | ALDH2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
