CMAUP Plant Collective Molecular Activities

Plant Name: Orobanche coerulescens

Taxonomic Information:

Plant ID: NPO23170
Plant Latin Name: Orobanche coerulescens
Taxonomy Genus: Orobanche
Taxonomy Family: Orobanchaceae

Plant External Links:

NCBI TaxonomyDB: 223100
Plant-of-the-World-Online: 662192-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Ukraine; Romania; South Africa; Poland; Austria; China; Germany; Hungary; Japan; Kazakhstan; Russia

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	PTPN1;
Enzyme_unclassified	TDP1; HSD17B10;
Protein Kinase	PRKCA;
Lyase	CA2; CA1; CA12; CA9; CA7; CA3; CA14; CA5B; CA5A; CA6;
Lysine demethylase	KDM4E;
Metallo protease	MMP9; MMP1; MMP12; MMP2;
Transcription Factor	HIF1A; NFKB1;
Unclassified	RAB9A; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	6.184E-08	1.122E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	1.770E-07	2.570E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.953E-27	6.430E-23	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	1.180E-06	1.427E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	2.587E-06	2.450E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	3.863E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	1.155E-05	8.793E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.394E-21	2.606E-17	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.173E-19	6.386E-16	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.864E-15	6.766E-12	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PRKCA, PTPN1
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.213E-05	1.554E-02	CA1, CA2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.349E-26	1.632E-24	CA12, CA1, CA3, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.857E-06	3.543E-04	MMP1, MMP2, PRKCA, HIF1A, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.571E-05	6.335E-04	MMP1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	9.337E-05	2.825E-03	MMP2, PRKCA, HIF1A, MMP9
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.342E-04	5.005E-03	MMP2, PRKCA, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.482E-04	5.005E-03	PRKCA, HIF1A, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	6.893E-04	1.043E-02	PRKCA, MMP9, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	3.702E-04	6.398E-03	MMP2, PRKCA, MMP9
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	2.341E-03	3.147E-02	PRKCA, HIF1A
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	3.536E-03	3.890E-02	CA2, PRKCA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9; MMP2;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; MMP9; MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases