CMAUP Plant Collective Molecular Activities

Plant Name: Maclura cochinchinensis

Taxonomic Information:

Plant ID: NPO23156
Plant Latin Name: Maclura cochinchinensis
Taxonomy Genus: Maclura
Taxonomy Family: Moraceae

Plant External Links:

NCBI TaxonomyDB: 194324
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Thailand

Traditional Medicine System:

Geographical Distribution:

Thailand

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Taste receptor (taste family GPCR)	TAS2R31;
Small molecule receptor (family A GPCR)	ADORA3;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1;
Potassium channels	KCNA3;
Nuclear hormone receptor subfamily 3 group A	ESR1;
Nuclear hormone receptor subfamily 1 group B	RARA;
ATP-binding cassette	ABCB1; ABCG2;
Unclassified	LMNA; RAB9A; NPC1; HSP90AA1; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP19A1; CYP3A4; CYP1A2; CYP1B1; CYP1A1; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group B	RARA	Retinoic acid receptor alpha	P10276	CHEMBL2055
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Potassium channels	KCNA3	Voltage-gated potassium channel subunit Kv1.3	P22001	CHEMBL4633
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Taste receptor (taste family GPCR)	TAS2R31	Taste receptor type 2 member 31	P59538	CHEMBL2034804
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	CHEMBL3880
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.138E-14	1.239E-10	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.859E-13	8.098E-10	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.763E-13	1.482E-09	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	2.005E-12	5.458E-09	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.221E-11	2.216E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.811E-11	6.384E-08	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	9.011E-10	1.033E-06	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	9.011E-10	1.033E-06	CYP1A2, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	6.736E-09	6.111E-06	CYP1A2, CYP2C9, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	8.378E-07	5.068E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4, RAB9A
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.936E-06	1.453E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	4.300E-06	2.012E-03	CYP19A1, CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	4.435E-06	2.012E-03	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	4.435E-06	2.012E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0008209; androgen metabolic process	5.410E-06	2.404E-03	CYP19A1, CYP3A4, ESR1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	8.864E-06	3.784E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	1.476E-05	5.740E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	2.213E-05	8.166E-03	CYP1A1, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.214E-16	6.999E-12	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	9.691E-05	2.891E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	1.144E-04	3.236E-02	SMN1, SMN2
CC	GO:0016020; membrane	GO:0031090; organelle membrane	1.766E-04	4.633E-02	ABCG2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4, LMNA, NPC1, RAB9A
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	1.951E-04	4.979E-02	ABCG2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4, ESR1, HSP90AA1, LMNA, MAPT, NPC1, RAB9A, RARA, SMN1, SMN2, TDP1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.449E-10	1.151E-08	CYP2C9, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.003E-10	1.176E-08	CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.006E-09	1.098E-07	CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.704E-08	2.002E-07	CYP2C9, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.712E-08	3.489E-07	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.028E-06	8.053E-06	CYP2C9, CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.457E-05	9.782E-05	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.868E-05	1.685E-04	CYP1A1, CYP1B1, CYP19A1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	8.225E-05	4.295E-04	ABCB1, CYP3A4, ABCG2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.176E-04	1.493E-03	CYP2C9, CYP2D6, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.497E-03	9.782E-03	CYP2C9, CYP2C19
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	1.266E-03	5.409E-03	ABCB1, ABCG2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1;
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1;
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	KCNA3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	RARA;
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic arthritis	L40.5, M07	KCNA3;
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1;
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1;
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1;
NA: NA	Postmenopausal disorder	NA	ESR1;
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1;
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1;
C00-D49: Neoplasms	Solid tumours	C00-D48	RARA;
NA: NA	Menopausal disorder	NA	ESR1;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1;
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1;
C00-D49: Neoplasms	Breast cancer	C50	ESR1; CYP19A1;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
NA: NA	Gonorrheal vaginitis	NA	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1;
A00-B99: Certain infectious and parasitic diseases	Acquired immune deficiency syndrome	B20	RARA;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Cancer	C00-C96	ESR1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1;
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1;
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	RARA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1;
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1;
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases