CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	HSD17B10; HPGD; ALDH1A1;
Cysteine protease	CASP7; CASP1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047

Showing 1 to 6 of 6 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0097194; execution phase of apoptosis	5.625E-05	2.416E-01	CASP1, CASP7
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	5.651E-05	2.416E-01	CASP1, HPGD, NR1H4
BP	GO:0009987; cellular process	GO:0010803; regulation of tumor necrosis factor-mediated signaling pathway	1.365E-04	2.416E-01	CASP1, NR1H4
BP	GO:0008152; metabolic process	GO:0006629; lipid metabolic process	2.075E-04	2.416E-01	ALDH1A1, HPGD, HSD17B10, NR1H4
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	2.641E-04	2.416E-01	CASP1, CASP7
MF	GO:0003824; catalytic activity	GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis	6.262E-06	1.049E-01	CASP1, CASP7
MF	GO:0005488; binding	GO:0051287; NAD binding	1.365E-04	2.416E-01	ALDH1A1, HPGD

Showing 1 to 7 of 7 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1.432E-02	3.754E-02	HSD17B10
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.934E-02	3.754E-02	ALDH1A1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.698E-02	3.754E-02	CASP1
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	1.905E-02	3.754E-02	CASP1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.111E-02	3.754E-02	NR1H4
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.106E-04	1.649E-03	CASP7, CASP1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	2.061E-04	1.649E-03	CASP7, CASP1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.029E-03	5.488E-03	CASP7, HSD17B10
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	1.520E-02	3.754E-02	CASP1
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	2.553E-02	4.084E-02	CASP1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Guettarda eximia

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities