CMAUP Plant Collective Molecular Activities

Plant Name: Aesculus hippocastanum

Taxonomic Information:

Plant ID: NPO23044
Plant Latin Name: Aesculus hippocastanum
Taxonomy Genus: Aesculus
Taxonomy Family: Sapindaceae

Plant External Links:

NCBI TaxonomyDB: 43364
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Turkey; Italy; India; Lebanon; China; Bulgaria

Traditional Medicine System:

TCM

Medicinal Functions:

Alterative; Analgesic; Antiinflammatory; Antirheumatic; Astringent; Bach; Diuretic; Expectorant; Febrifuge; Haemostatic; Narcotic; Tonic; Vasoconstrictor; Vulnerary

Geographical Distribution:

Turkey; Italy; India; Lebanon; China; Bulgaria

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA2; CA1; CA12; CA9; CA13; CA14; CA7; CA3; CA5B; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Enzyme_unclassified	HPGD; HSD17B10; ALOX15; ALDH1A1;
Cysteine protease	CASP1; CASP7;
Transcription Factor	HIF1A;
Unclassified	HTT;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.251E-11	2.477E-08	CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.234E-35	1.140E-30	CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.393E-27	2.605E-23	CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.199E-25	6.527E-22	CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.712E-06	4.255E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	1.852E-05	1.754E-02	ALOX15, HPGD
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.852E-05	1.754E-02	CA1, CA2
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	5.316E-05	4.823E-02	CA2, CA4, CA9, HPGD
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	5.542E-05	4.827E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.684E-34	1.827E-32	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14, CA13
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.882E-04	5.619E-03	CA2, CA4
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.656E-03	2.152E-02	CASP7, CASP1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	3.053E-03	2.977E-02	CASP7, CASP1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.451E-02	9.432E-02	CASP7, HSD17B10
09100 Metabolism	09105 Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5.152E-02	1.389E-01	HSD17B10
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.144E-02	1.389E-01	ALOX15
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4.942E-02	1.389E-01	XDH
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	6.399E-02	1.389E-01	HIF1A
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	5.488E-03	4.281E-02	XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases