CMAUP Plant Collective Molecular Activities

Plant Name: Glycyrrhiza kansuensis

Taxonomic Information:

Plant ID: NPO23019
Plant Latin Name: Glycyrrhiza kansuensis
Taxonomy Genus: Glycyrrhiza
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	AKR1B1; HSD17B2; HSD11B1; HSD11B2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	HSD11B2	11-beta-hydroxysteroid dehydrogenase 2	P80365	CHEMBL3746

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	4.642E-06	6.738E-03	AKR1B1, HSD11B1, HSD11B2, HSD17B2
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	4.168E-04	2.928E-01	HSD11B1, HSD11B2, HSD17B2
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.380E-02	1.000E+00	AKR1B1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9.239E-08	9.239E-07	HSD11B1, HSD11B2, HSD17B2
Unclassified	Unclassified	hsa01100	Metabolic pathways	9.049E-04	4.524E-03	HSD11B1, HSD17B2, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	7.181E-03	1.296E-02	AKR1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	9.963E-03	1.423E-02	HSD17B2
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.987E-03	1.296E-02	AKR1B1
09150 Organismal Systems	09155 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7.778E-03	1.296E-02	HSD11B2
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6.385E-03	1.296E-02	AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.175E-02	1.469E-02	AKR1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.452E-02	1.613E-02	HSD11B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.630E-02	1.630E-02	HSD11B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B2;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases