CMAUP Plant Collective Molecular Activities

Plant Name: Zephyranthes carinata

Taxonomic Information:

Plant ID: NPO23000
Plant Latin Name: Zephyranthes carinata
Taxonomy Genus: Zephyranthes
Taxonomy Family: Amaryllidaceae

Plant External Links:

NCBI TaxonomyDB: 879247
Plant-of-the-World-Online: 270933-2

Used in Medicines:

Country/Region:

Argentina

Traditional Medicine System:

Geographical Distribution:

Brazil; Jamaica; Australia; Honduras; Peru; Mexico; Nepal; India; Costa Rica; South Africa; New Caledonia; United States; Guatemala; Zimbabwe; China; Colombia; Sri Lanka; Argentina; Nicaragua

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	CDC25B;
Enzyme_unclassified	RECQL;
Protein Kinase	AURKB; AURKA; KDR;
Lyase	CA14; CA7; CA5A; CA6; CA9; CA5B;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP2; MMP9; MMP1;
Transcription Factor	NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.599E-12	2.830E-08	CA14, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.921E-10	6.971E-07	CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.081E-09	3.362E-06	CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, NR1H4, RORC
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.874E-15	4.081E-11	CA14, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.757E-15	2.893E-13	CA5B, CA5A, CA7, CA6, CA9, CA14
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	7.574E-06	2.916E-04	MMP1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.549E-04	3.976E-03	CYP1B1, MMP9, NFKB1, CDC25B
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	4.679E-04	9.008E-03	MMP1, MMP2, MMP9, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Breast cancer	C50	KDR; CA9;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	KDR; MMP9;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	AURKA; AURKB; KDR; MMP9; MMP2; CA9;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	KDR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Cancer	C00-C96	AURKA; KDR; NFKB1; MMP9; MMP2; CDC25B; CA9;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR; MMP2;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKA; AURKB;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; MMP2;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Liver cancer	C22	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
C00-D49: Neoplasms	AML	NA	KDR;
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases