Plant Name: Actinidia deliciosa
Taxonomic Information:
Plant ID: NPO2300
Plant Latin Name: Actinidia deliciosa
Taxonomy Genus: Actinidia
Taxonomy Family: Actinidiaceae
Plant External Links:
NCBI TaxonomyDB:
3627
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Unknown.
Geographical Distribution:
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| PTPN1; | |
| HSD17B10; | |
| HIF1A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0030947; regulation of vascular endothelial growth factor receptor signaling pathway | 1.044E-05 | 2.272E-01 | HIF1A, PTPN1 |
| BP | GO:0009987; cellular process | GO:2001243; negative regulation of intrinsic apoptotic signaling pathway | 1.427E-04 | 4.696E-01 | HIF1A, PTPN1 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 8.281E-04 | 4.696E-01 | PTPN1 |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 4.141E-04 | 4.696E-01 | TSHR |
| CC | GO:0044464; cell part | GO:0097443; sorting endosome | 1.242E-03 | 4.917E-01 | PTPN1 |
| MF | GO:0005488; binding | GO:0019901; protein kinase binding | 5.153E-03 | 7.980E-01 | HIF1A, PTPN1 |
| MF | GO:0005488; binding | GO:0035035; histone acetyltransferase binding | 5.580E-03 | 8.266E-01 | HIF1A |
| CC | GO:0016020; membrane | GO:0005886; plasma membrane | 3.923E-02 | 1.000E+00 | HSD17B10, PTPN1, TSHR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00280 | Valine, leucine and isoleucine degradation | 9.566E-03 | 3.496E-02 | HSD17B10 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 1.056E-02 | 3.496E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.115E-02 | 3.496E-02 | TSHR |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04150 | mTOR signaling pathway | 1.195E-02 | 3.496E-02 | HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05211 | Renal cell carcinoma | 1.314E-02 | 3.496E-02 | HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.333E-02 | 3.496E-02 | HIF1A |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.413E-02 | 3.496E-02 | TSHR |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.472E-02 | 3.496E-02 | PTPN1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 2.162E-02 | 3.704E-02 | PTPN1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 2.339E-02 | 3.704E-02 | HIF1A |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
