Plant Name: Cyperus rotundus
Taxonomic Information:
Plant ID: NPO22796
Plant Latin Name: Cyperus rotundus
Taxonomy Genus: Cyperus
Taxonomy Family: Cyperaceae
Plant External Links:
NCBI TaxonomyDB:
512623
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Brazil; Rwanda; Philippines; Indonesia; India; Laos; Malaysia; Vietnam; Jordan; Sri Lanka; China; Kenya; Paraguay; Thailand; South Korea; Tanzania; NigeriaTraditional Medicine System:
Sowa-Rigpa; Unani; Siddha; Ayurveda; Kampo; TCMMedicinal Functions:
Analgesic; Antibacterial; Antibiotic; Antispasmodic; Antitussive; Aromatic; Astringent; Carminative; Contraceptive; Diaphoretic; Diuretic; Emmenagogue; Lithontripic; Sedative; Skin; Stimulant; Stomachic; Tonic; Vermifuge
Geographical Distribution:
Brazil; Thailand; Philippines; Indonesia; India; Jordan; Malaysia; Rwanda; China; Sri Lanka; Vietnam; Laos; Paraguay; Kenya; Nigeria; Tanzania; South Korea
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| MAPK1; | |
| PPARA; PPARD; | |
| ALOX15; | |
| CASP1; CASP7; | |
| TLR2; | |
| HIF1A; TP53; | |
| MAPT; FABP3; FABP2; FABP4; LMNA; FABP5; | |
| XDH; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 5.134E-09 | 1.206E-05 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0050896; response to stimulus | GO:0042060; wound healing | 5.340E-07 | 4.235E-04 | ALOX15, PPARA, PPARD, TP53 |
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 6.883E-07 | 4.835E-04 | CASP1, CASP7, MAPT, XDH |
| BP | GO:0032501; multicellular organismal process | GO:0001816; cytokine production | 7.228E-07 | 4.918E-04 | CASP1, FABP4, HIF1A, TLR2 |
| BP | GO:0008152; metabolic process | GO:0009299; mRNA transcription | 1.287E-06 | 7.573E-04 | HIF1A, PPARD, TP53 |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.788E-06 | 9.497E-04 | HIF1A, LMNA, PPARD, TP53 |
| BP | GO:0009987; cellular process | GO:1902533; positive regulation of intracellular signal transduction | 1.045E-05 | 3.455E-03 | ALOX15, CASP1, MAPK1, PPARD, TLR2, TP53, XDH |
| BP | GO:0009987; cellular process | GO:0071345; cellular response to cytokine stimulus | 1.052E-05 | 3.455E-03 | ALOX15, CASP1, FABP4, HIF1A, MAPK1 |
| MF | GO:0005488; binding | GO:0019902; phosphatase binding | 1.094E-05 | 3.455E-03 | MAPK1, MAPT, PPARA, TP53 |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 1.255E-05 | 3.848E-03 | ALOX15, CASP1, CASP7, FABP2, FABP3, FABP4, FABP5, HIF1A, LMNA, MAPK1, MAPT, TP53, XDH |
| MF | GO:0005488; binding | GO:0097371; MDM2/MDM4 family protein binding | 1.527E-05 | 4.545E-03 | PPARA, TP53 |
| BP | GO:0050896; response to stimulus | GO:0050727; regulation of inflammatory response | 1.616E-05 | 4.630E-03 | CASP1, FABP4, PPARA, PPARD, TLR2 |
| BP | GO:0008283; cell proliferation | GO:0008285; negative regulation of cell proliferation | 2.012E-05 | 5.155E-03 | FABP3, LMNA, PPARD, TLR2, TP53, XDH |
| BP | GO:0009987; cellular process | GO:0019896; axonal transport of mitochondrion | 2.615E-05 | 6.200E-03 | HIF1A, MAPT |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 2.620E-05 | 6.200E-03 | FABP3, PPARA, PPARD |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 2.620E-05 | 6.200E-03 | HIF1A, MAPK1, MAPT |
| BP | GO:0009987; cellular process | GO:0010821; regulation of mitochondrion organization | 3.853E-05 | 8.146E-03 | HIF1A, LMNA, MAPT, TP53 |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 3.991E-05 | 8.199E-03 | PPARA, PPARD |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 3.991E-05 | 8.199E-03 | FABP3, PPARD |
| BP | GO:0009987; cellular process | GO:0050714; positive regulation of protein secretion | 4.487E-05 | 8.717E-03 | CASP1, HIF1A, PPARD, TLR2 |
| BP | GO:0007610; behavior | GO:0007611; learning or memory | 4.487E-05 | 8.717E-03 | HIF1A, MAPK1, MAPT, TLR2 |
| MF | GO:0003824; catalytic activity | GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis | 5.654E-05 | 1.043E-02 | CASP1, CASP7 |
| MF | GO:0005488; binding | GO:0008134; transcription factor binding | 1.192E-04 | 1.824E-02 | HIF1A, MAPK1, PPARA, PPARD, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.621E-11 | 2.043E-09 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 5.100E-06 | 3.213E-04 | CASP7, LMNA, MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 2.211E-05 | 5.954E-04 | MAPK1, TP53, HIF1A, TLR2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.302E-05 | 5.469E-04 | CASP7, CASP1, TLR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 2.363E-05 | 5.954E-04 | MAPK1, TP53, HIF1A |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 3.316E-05 | 6.965E-04 | CASP7, CASP1, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.282E-04 | 2.307E-03 | MAPK1, TP53, HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 2.965E-04 | 3.396E-03 | MAPK1, HIF1A, TP53, PPARD |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 2.404E-04 | 3.366E-03 | MAPK1, TP53, TLR2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 1.826E-04 | 2.876E-03 | MAPK1, PPARA, TP53 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 3.631E-04 | 3.812E-03 | CASP7, MAPK1, MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 5.953E-04 | 5.358E-03 | MAPK1, PPARA, TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 2.724E-04 | 3.396E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 1.019E-03 | 6.652E-03 | MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 1.220E-03 | 6.837E-03 | MAPK1, MAPT, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 5.469E-04 | 5.300E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05213 | Endometrial cancer | 8.795E-04 | 6.652E-03 | MAPK1, TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.019E-03 | 6.652E-03 | FABP4, TSHR |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 8.461E-04 | 6.652E-03 | CASP1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.056E-03 | 6.652E-03 | MAPK1, PPARD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04150 | mTOR signaling pathway | 1.169E-03 | 6.837E-03 | MAPK1, HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 1.371E-03 | 6.846E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 1.248E-03 | 6.837E-03 | MAPK1, TP53 |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 1.056E-03 | 6.652E-03 | CASP1, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 1.413E-03 | 6.846E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05211 | Renal cell carcinoma | 1.413E-03 | 6.846E-03 | MAPK1, HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 1.633E-03 | 7.494E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 1.725E-03 | 7.494E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 1.725E-03 | 7.494E-03 | MAPK1, TLR2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MAPK1; TP53; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MAPK1; TP53; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
