CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1;
Hydrolase	ACHE;
Protein Kinase	FLT3; CSNK2A1;
Enzyme_unclassified	ADK; NOX4; HSD17B1;
Lyase	CA2; CA7; CA4; CA12;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Metallo protease	MMP12;
Transcription Factor	HIF1A;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.944E-08	1.079E-04	CA12, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	9.264E-08	1.552E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.322E-07	1.977E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.362E-07	1.977E-04	CA12, CA2, CA4, CA7
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	3.145E-07	3.886E-04	ADORA2A, CA2, CA7
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	5.102E-07	5.555E-04	ADORA2A, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, NOX4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.454E-06	1.218E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.934E-06	1.504E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	2.759E-06	1.821E-03	ADORA1, ADORA2A, ADORA3, CSNK2A1, CYP1B1, FLT3, HIF1A, MMP12, NOX4, THPO
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.375E-06	1.986E-03	CA2, CA7

Showing 1 to 10 of 20 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.377E-09	9.286E-08	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.118E-09	9.286E-08	CA12, CA2, CA4, CA7
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	9.614E-06	1.322E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.919E-05	6.510E-04	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.004E-07	3.675E-06	HSD17B1, CYP1A1, CYP1B1, CYP19A1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.622E-04	2.060E-03	CA2, CA4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	8.376E-05	7.678E-04	CYP1A2, CYP1A1, CYP1B1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
C00-D49: Neoplasms	Pancreatic cancer	C25	FLT3;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Angylocalyx braunii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities