CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF; PTPN11; PTPN6; CDC25B;
Enzyme_unclassified	PLA2G1B; CES1; RECQL; TDP1; TERT; HSD11B1; AKR1B10; AKR1B1; CES2; POLB;
Hydrolase	ACHE;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	STAT3;
Unclassified	APAF1; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	CES1	Acyl coenzyme A:cholesterol acyltransferase	P23141	CHEMBL2265
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	CES2	Carboxylesterase 2	O00748	CHEMBL3180
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392

Showing 1 to 10 of 24 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	2.414E-11	2.168E-07	ACP1, CDC25B, PTPN1, PTPN11, PTPN2, PTPN6, PTPRF
BP	GO:0009987; cellular process	GO:0060338; regulation of type I interferon-mediated signaling pathway	2.888E-07	5.717E-04	PTPN1, PTPN11, PTPN2, PTPN6
BP	GO:0009987; cellular process	GO:0033277; abortive mitotic cell cycle	1.480E-06	2.301E-03	PTPN11, PTPN6
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.435E-06	4.599E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	6.589E-06	6.238E-03	AKR1B1, APAF1, MAPT, POLB, PTPN1, PTPN11, PTPRF, RECQL, TDP1, TERT
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	8.864E-06	7.423E-03	PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.144E-05	8.590E-03	AKR1B1, AKR1B10, CES1, HSD11B1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	9.399E-08	2.274E-04	ACP1, PTPN11, PTPN2
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	4.435E-06	4.599E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0047374; methylumbelliferyl-acetate deacetylase activity	4.435E-06	4.599E-03	CES1, CES2

Showing 1 to 10 of 12 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	8.480E-04	9.894E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.881E-04	9.375E-03	AKR1B10, AKR1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.383E-03	1.383E-02	CES2, CES1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6.696E-04	9.375E-03	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	2.265E-03	1.761E-02	AKR1B10, AKR1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	3.522E-05	8.219E-04	STAT3, PTPN6, PTPN11, PTPN2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.735E-06	1.214E-04	PTPN1, PTPN6, ACP1, PTPRF
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	8.155E-06	2.854E-04	PTPN1, STAT3, PTPN11, PTPRF
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.782E-03	1.559E-02	STAT3, PTPN6, PTPN11
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	2.741E-03	1.919E-02	STAT3, RORC

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	CES1;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; CDC25B;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1; CES1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1;

Showing 1 to 10 of 37 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Picradeniopsis pringlei

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities