CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NMUR2;
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A;
Enzyme_unclassified	RECQL; TDP1; BLM; HPGD; PGD; AKR1B1; GFER; HSD17B10; ALOX15; ALDH1A1; POLB;
Hydrolase	GAA; ACHE;
Miscellaneous ion channel	BCL2;
Protein Kinase	MET; MAPK1; MAPK14; PIM1; CSNK2A1;
Lyase	CA2; CA1; CA12; CA9; CA5B; CA3; CA14; CA7; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Lysine demethylase	KDM4E;
Serine protease	ELANE;
Transcription Factor	HIF1A;
Transferase	FUT7;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	LMNA; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159

Showing 1 to 10 of 47 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	1.232E-06	1.412E-03	ADRA2A, AKR1B1, BCL2, CSNK2A1, ELANE, ESR1, HIF1A, HPGD, MAPK1, MAPK14, PIM1, TSHR
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.402E-06	1.527E-03	AKR1B1, ALDH1A1, ALOX15, CYP2C9, CYP3A4, GAA, GFER, HPGD, HSD17B10, KDM4E, MAPK14, PGD
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	1.333E-05	8.750E-03	AKR1B1, ALOX15, BCL2, BLM, CA2, CA9, HIF1A, LMNA, MAPK1, MAPK14, MAPT, POLB, RECQL, TDP1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.687E-20	5.103E-16	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.983E-19	3.476E-15	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.726E-08	3.132E-05	ADRA2A, CA2, CA4, CA9, HPGD, SLCO1B1, SLCO1B3, TSHR
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	2.293E-05	1.251E-02	AKR1B1, HIF1A, MAPK1, MAPT
MF	GO:0005488; binding	GO:0008270; zinc ion binding	5.818E-08	9.048E-05	BLM, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.778E-27	1.911E-22	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	6.047E-06	4.540E-03	ESR1, ESR2

Showing 1 to 10 of 11 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.410E-26	8.061E-24	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.537E-05	1.690E-03	CYP2C9, ALOX15, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5.105E-04	9.238E-03	CYP2C9, ALDH1A1, CYP3A4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	7.462E-04	1.112E-02	CSNK2A1, MAPK1, MET
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	2.665E-05	1.324E-03	MAPK1, MAPK14, ESR1, ESR2
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.521E-05	1.324E-03	SLCO1B1, CA2, SLCO1B3, CYP3A4
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.005E-04	2.995E-03	PIM1, BCL2, MAPK1, MAPK14
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.232E-04	3.059E-03	MAPK1, MAPK14, HIF1A, ESR1, MET
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	5.339E-04	9.238E-03	MAPK1, MET, HIF1A
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	5.580E-04	9.238E-03	MAPK1, MET, HIF1A

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; BCL2;
C00-D49: Neoplasms	Breast cancer	C50	BCL2;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
C00-D49: Neoplasms	Prostate cancer	C61	BCL2;
C00-D49: Neoplasms	Leukemia	C90-C95	BCL2;
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
C00-D49: Neoplasms	Multiple myeloma	C90	BCL2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Helichrysum chionosphaerum

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities