CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1; FFAR1; FFAR4; HCAR2;
Enzyme_unclassified	RECQL; ADK; HSD17B2; ALOX15;
Lyase	CA2; CA12; CA7;
Oxidoreductase	TYR;
Transcription Factor	AHR;
Unclassified	LMNA; FABP3; FABP4;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	7.617E-08	4.653E-04	ADORA1, ADORA2A, CYP1A1, CYP1B1, FFAR1, FFAR4, HCAR2, HSD17B2
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	1.233E-07	5.369E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.760E-07	6.387E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	4.185E-07	1.123E-03	ADORA2A, CA2, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.934E-06	3.008E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.571E-06	3.294E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.066E-06	3.688E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	8.126E-06	5.362E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.026E-05	6.385E-03	CA12, CA2, CA7
BP	GO:0008152; metabolic process	GO:0016042; lipid catabolic process	1.408E-05	8.026E-03	ADORA1, CYP1A2, CYP1B1, FABP3, FABP4

Showing 1 to 10 of 17 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.410E-07	1.833E-05	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.277E-05	1.745E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.939E-07	1.833E-05	CA12, CA2, CA7
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.840E-05	6.429E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.040E-04	2.952E-03	CYP1A2, ALOX15
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.518E-03	9.385E-03	CYP1A2, CYP1A1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.484E-03	7.604E-03	HCAR2, ADORA2A, ADORA1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.514E-05	2.576E-04	HSD17B2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.876E-03	8.546E-03	FABP4, ADORA1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.832E-03	9.676E-03	FABP3, FABP4

Showing 1 to 10 of 12 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3;
C00-D49: Neoplasms	Multiple myeloma	C90	AHR;
C00-D49: Neoplasms	Melanoma	C43	TYR;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HCAR2; FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;

Showing 1 to 10 of 57 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Haematococcus lacustris

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities