Plant Name: Pteris glauca
Taxonomic Information:
Plant ID: NPO22632
Plant Latin Name: Pteris glauca
Taxonomy Genus: Pteris
Taxonomy Family: Pteridaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| IKBKB; | |
| NR1H4; | |
| AKR1B10; | |
| MCL1; TXN2; TXN; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Kinase | IKBKB | Inhibitor of nuclear factor kappa B kinase beta subunit | O14920 | CHEMBL1991 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
| Unclassified | TXN2 | Thioredoxin, mitochondrial | Q99757 | CHEMBL2189153 |
| Unclassified | TXN | Thioredoxin | P10599 | CHEMBL2010624 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 3.377E-07 | 3.676E-03 | GPBAR1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0006662; glycerol ether metabolic process | 6.182E-06 | 4.487E-02 | TXN, TXN2 |
| BP | GO:0009987; cellular process | GO:0060548; negative regulation of cell death | 1.836E-04 | 2.509E-01 | IKBKB, MCL1, NR1H4, TXN |
| BP | GO:0009987; cellular process | GO:0010803; regulation of tumor necrosis factor-mediated signaling pathway | 1.907E-04 | 2.509E-01 | IKBKB, NR1H4 |
| BP | GO:0009987; cellular process | GO:0045454; cell redox homeostasis | 2.764E-04 | 2.509E-01 | TXN, TXN2 |
| CC | GO:0032991; macromolecular complex | GO:0097136; Bcl-2 family protein complex | 2.173E-03 | 5.735E-01 | MCL1 |
| CC | GO:0044464; cell part | GO:0005739; mitochondrion | 8.520E-03 | 1.000E+00 | MCL1, TXN, TXN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 9.984E-04 | 4.593E-02 | IKBKB, MCL1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 5.752E-03 | 5.813E-02 | IKBKB, MCL1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04930 | Type II diabetes mellitus | 1.668E-02 | 5.813E-02 | IKBKB |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.978E-02 | 5.813E-02 | IKBKB |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.045E-02 | 5.813E-02 | AKR1B10 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 1.115E-02 | 5.813E-02 | AKR1B10 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04150 | mTOR signaling pathway | 2.082E-02 | 5.813E-02 | IKBKB |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 2.047E-02 | 5.813E-02 | AKR1B10 |
| 09150 Organismal Systems | 09151 Immune system | hsa04622 | RIG-I-like receptor signaling pathway | 2.425E-02 | 5.813E-02 | IKBKB |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.459E-02 | 5.813E-02 | NR1H4 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | MCL1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
