CMAUP Plant Collective Molecular Activities

Plant Name: Atractylodes macrocephala koidz

Taxonomic Information:

Plant ID: NPO22562
Plant Latin Name: Atractylodes macrocephala koidz
Taxonomy Genus: Atractylodes
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family C GPCR)	GRM8; GRM1;
Small molecule receptor (family A GPCR)	ADORA3;
Enzyme_unclassified	BLM; CDA;
Ionotropic glutamate receptor	GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
Lyase	CA9;
Transcription Factor	NFKB1;
SLC superfamily of solute carriers	SLC1A1;
Unclassified	FABP4; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Ionotropic glutamate receptor	GRIA4	Glutamate receptor ionotropic, AMPA 4	P48058	CHEMBL3190
Ionotropic glutamate receptor	GRIA2	Glutamate receptor ionotropic, AMPA 2	P42262	CHEMBL4016
Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
SLC superfamily of solute carriers	SLC1A1	Excitatory amino acid transporter 3	P43005	CHEMBL2721
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family C GPCR)	GRM8	Metabotropic glutamate receptor 8	O00222	CHEMBL3228
Small molecule receptor (family C GPCR)	GRM1	Metabotropic glutamate receptor 1	Q13255	CHEMBL3772
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005215; transporter activity	GO:0005234; extracellularly glutamate-gated ion channel activity	2.253E-12	1.226E-08	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	1.270E-11	5.532E-08	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	2.126E-09	3.858E-06	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0015277; kainate selective glutamate receptor activity	4.658E-09	6.762E-06	GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0007196; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	3.905E-08	5.002E-05	GRIK3, GRM1, GRM8
BP	GO:0023052; signaling	GO:0051966; regulation of synaptic transmission, glutamatergic	1.390E-07	1.513E-04	GRIK1, GRIK3, GRM1, GRM8
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	5.875E-07	5.815E-04	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0004971; AMPA glutamate receptor activity	3.856E-06	2.399E-03	GRIA2, GRIA4
MF	GO:0005215; transporter activity	GO:0008381; mechanosensitive ion channel activity	5.522E-06	3.006E-03	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
CC	GO:0044425; membrane part	GO:0008328; ionotropic glutamate receptor complex	6.926E-06	3.588E-03	GRIA2, GRIA4, GRIK5
MF	Unclassified;	GO:0004872; receptor activity	1.239E-05	5.506E-03	ADORA3, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, GRM1, GRM8
CC	GO:0044456; synapse part	GO:0042734; presynaptic membrane	1.712E-05	7.168E-03	GRIK5, GRM1, GRM8

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	1.076E-14	9.466E-13	GRIA2, GRIK5, SLC1A1, GRM8, GRIK3, GRIK1, GRM1, GRIA4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.431E-11	6.297E-10	GRIA2, GRIK5, ADORA3, GRM8, GRIK3, GRIK1, GRM1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	6.674E-05	1.958E-03	GRIA2, GRM1, GRIA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	4.939E-04	8.678E-03	GRIA2, NFKB1, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	4.598E-04	8.678E-03	GRIA2, GRIA4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6.084E-04	8.678E-03	CDA, CYP3A4
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	6.903E-04	8.678E-03	GRIA2, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; ADORA3; CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	GRM1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	GRIK1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	GRM1; GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	GRIA2; GRIA4;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	GRM1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	GRM1; GRIK1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	GRM1; GRIK1;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	GRM1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	GRIK1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3;
C00-D49: Neoplasms	Solid tumours	C00-D48	CDA; CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases