CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family C GPCR)	GRM8; GRM1;
Small molecule receptor (family A GPCR)	ADORA3;
Enzyme_unclassified	BLM; CDA;
Ionotropic glutamate receptor	GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
Lyase	CA9;
Transcription Factor	NFKB1;
SLC superfamily of solute carriers	SLC1A1;
Unclassified	FABP4; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Ionotropic glutamate receptor	GRIA4	Glutamate receptor ionotropic, AMPA 4	P48058	CHEMBL3190
Ionotropic glutamate receptor	GRIA2	Glutamate receptor ionotropic, AMPA 2	P42262	CHEMBL4016
Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
SLC superfamily of solute carriers	SLC1A1	Excitatory amino acid transporter 3	P43005	CHEMBL2721

Showing 1 to 10 of 16 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	1.270E-11	5.532E-08	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	2.126E-09	3.858E-06	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0007196; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	3.905E-08	5.002E-05	GRIK3, GRM1, GRM8
BP	GO:0023052; signaling	GO:0051966; regulation of synaptic transmission, glutamatergic	1.390E-07	1.513E-04	GRIK1, GRIK3, GRM1, GRM8
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	5.875E-07	5.815E-04	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
CC	GO:0044425; membrane part	GO:0008328; ionotropic glutamate receptor complex	6.926E-06	3.588E-03	GRIA2, GRIA4, GRIK5
CC	GO:0044456; synapse part	GO:0042734; presynaptic membrane	1.712E-05	7.168E-03	GRIK5, GRM1, GRM8
MF	GO:0005215; transporter activity	GO:0005234; extracellularly glutamate-gated ion channel activity	2.253E-12	1.226E-08	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0015277; kainate selective glutamate receptor activity	4.658E-09	6.762E-06	GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0004971; AMPA glutamate receptor activity	3.856E-06	2.399E-03	GRIA2, GRIA4

Showing 1 to 10 of 12 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6.084E-04	8.678E-03	CDA, CYP3A4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.431E-11	6.297E-10	GRIA2, GRIK5, ADORA3, GRM8, GRIK3, GRIK1, GRM1, GRIA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	4.939E-04	8.678E-03	GRIA2, NFKB1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	1.076E-14	9.466E-13	GRIA2, GRIK5, SLC1A1, GRM8, GRIK3, GRIK1, GRM1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	6.674E-05	1.958E-03	GRIA2, GRM1, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	4.598E-04	8.678E-03	GRIA2, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	6.903E-04	8.678E-03	GRIA2, NFKB1

Showing 1 to 7 of 7 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; ADORA3; CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CDA; CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Atractylodes macrocephala koidz

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities