CMAUP Plant Collective Molecular Activities

Plant Name: Ranunculus sceleratus

Taxonomic Information:

Plant ID: NPO22524
Plant Latin Name: Ranunculus sceleratus
Taxonomy Genus: Ranunculus
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: 147635
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Medicinal Functions:

Acrid; Anodyne; Antirheumatic; Antispasmodic; Diaphoretic; Emmenagogue; Rubefacient

Geographical Distribution:

India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA12; CA9; CA13;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Lysine demethylase	KDM4E;
Unclassified	RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.567E-09	1.648E-04	CA12, CA13, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.184E-07	1.290E-03	CA12, CA13, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.195E-07	1.593E-03	CA12, CA13, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.366E-05	1.056E-01	CA12, CA13, CA9, NR1H4
BP	GO:0065007; biological regulation	GO:0055081; anion homeostasis	6.558E-05	1.315E-01	CA12, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	9.316E-04	5.635E-01	NR1H4
CC	GO:0043226; organelle	GO:0042470; melanosome	3.097E-02	1.000E+00	RAB9A
CC	GO:0044464; cell part	GO:0005770; late endosome	4.121E-02	1.000E+00	RAB9A
CC	GO:0044464; cell part	GO:0043209; myelin sheath	4.481E-02	1.000E+00	CA13

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.019E-08	3.056E-08	CA12, CA9, CA13
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.111E-02	3.167E-02	NR1H4
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	4.012E-02	4.012E-02	RAB9A

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases