Plant ID: NPO22460
Plant Latin Name: Vernonia pachyclada
Taxonomy Genus: Vernonia
Taxonomy Family: Asteraceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
CTDSP1; TDP1; HSD17B1; AKR1B1; HSD17B2; GFER; ALOX15; NOX4; APEX1; POLB; | |
GAA; | |
DAPK1; FLT3; PIM1; | |
CA2; CA12; CA7; | |
AR; | |
ESRRA; | |
ALOX5; TYR; XDH; | |
KDM4E; | |
AHR; HIF1A; TP53; | |
ABCG2; ABCC1; | |
NPC1; LMNA; RAB9A; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
Enzyme_unclassified | CTDSP1 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | Q9GZU7 | CHEMBL1795098 |
Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Enzyme_unclassified | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
Enzyme_unclassified | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
Nuclear hormone receptor subfamily 3 group B | ESRRA | Estrogen-related receptor alpha | P11474 | CHEMBL3429 |
Nuclear hormone receptor subfamily 3 group C | AR | Androgen Receptor | P10275 | CHEMBL1871 |
Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
Oxidoreductase | TYR | Tyrosinase | P14679 | CHEMBL1973 |
Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
Protein Kinase | DAPK1 | Death-associated protein kinase 1 | P53355 | CHEMBL2558 |
Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
Transcription Factor | AHR | Aryl hydrocarbon receptor | P35869 | CHEMBL3201 |
Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 4.214E-12 | 2.294E-08 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9 |
MF | GO:0005488; binding | GO:0019825; oxygen binding | 2.089E-10 | 5.687E-07 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, NOX4 |
BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 3.353E-10 | 7.807E-07 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9 |
MF | GO:0005488; binding | GO:0005506; iron ion binding | 4.619E-10 | 8.692E-07 | ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, XDH |
BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.184E-07 | 8.320E-05 | CYP1A2, CYP2C19, CYP2C9 |
MF | GO:0005488; binding | GO:0020037; heme binding | 1.245E-07 | 8.475E-05 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, NOX4 |
BP | GO:0050896; response to stimulus | GO:0033993; response to lipid | 5.264E-07 | 2.729E-04 | AR, CA2, CYP1A1, CYP1A2, ESRRA, FLT3, HSD17B2, NPC1, TP53, TYR |
BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.293E-06 | 5.990E-04 | CYP1A2, CYP2C19, CYP2C9 |
BP | GO:0050896; response to stimulus | GO:0010038; response to metal ion | 1.736E-06 | 7.411E-04 | ALOX15, CA2, CYP1A1, CYP1A2, HIF1A, NPC1, TP53 |
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 2.664E-06 | 1.115E-03 | CA12, CA2, CA7 |
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 3.377E-06 | 1.337E-03 | APEX1, POLB |
BP | GO:0050896; response to stimulus | GO:0055093; response to hyperoxia | 7.727E-06 | 2.698E-03 | CYP1A1, POLB, TP53 |
BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.012E-05 | 3.190E-03 | CA2, CA7 |
BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 1.026E-05 | 3.190E-03 | CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0009987; cellular process | GO:0042981; regulation of apoptotic process | 1.055E-05 | 3.190E-03 | AKR1B1, APEX1, AR, CYP1B1, DAPK1, FLT3, HIF1A, LMNA, NOX4, PIM1, TP53, XDH |
MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 1.026E-05 | 3.190E-03 | CYP1A1, CYP1A2, CYP1B1 |
BP | GO:0008152; metabolic process | GO:2000377; regulation of reactive oxygen species metabolic process | 1.462E-05 | 4.128E-03 | CYP1B1, HIF1A, NOX4, TP53, XDH |
BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 2.022E-05 | 5.002E-03 | CYP1A1, CYP1A2 |
MF | GO:0005488; binding | GO:0005496; steroid binding | 1.935E-05 | 5.002E-03 | AR, ESRRA, HSD17B1, NPC1 |
MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 2.022E-05 | 5.002E-03 | CYP1A2, CYP2C9 |
BP | GO:0050896; response to stimulus | GO:0009725; response to hormone | 2.308E-05 | 5.519E-03 | AKR1B1, APEX1, AR, CA2, CYP1A2, ESRRA, FLT3, NPC1 |
BP | GO:0008283; cell proliferation | GO:0042127; regulation of cell proliferation | 2.419E-05 | 5.663E-03 | AHR, AKR1B1, AR, CYP1B1, ESRRA, FLT3, HIF1A, LMNA, NOX4, PIM1, TP53, XDH |
BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 2.578E-05 | 5.972E-03 | ABCC1, ALOX15, ALOX5 |
MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 3.419E-05 | 7.755E-03 | CYP1A1, CYP2C19, CYP2C9 |
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 4.069E-05 | 8.950E-03 | CA12, CA2, CA7 |
BP | GO:0065007; biological regulation | GO:0048878; chemical homeostasis | 4.475E-05 | 9.647E-03 | ABCG2, AKR1B1, CA12, CA2, CA7, HIF1A, NOX4, NPC1, TP53 |
BP | GO:0008152; metabolic process | GO:0017144; drug metabolic process | 4.595E-05 | 9.810E-03 | ABCC1, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9 |
MF | GO:0003824; catalytic activity | GO:0009055; electron transfer activity | 4.743E-05 | 9.836E-03 | AKR1B1, CYP1A2, NOX4, XDH |
CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 4.659E-05 | 9.836E-03 | ABCG2, AHR, AKR1B1, APEX1, AR, CTDSP1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, ESRRA, FLT3, GAA, GFER, HIF1A, KDM4E, LMNA, NOX4, NPC1, PIM1, POLB, RAB9A, TDP1, TP53, TYR, XDH |
CC | GO:0044464; cell part | GO:0005764; lysosome | 1.456E-04 | 2.426E-02 | AKR1B1, GAA, NPC1, RAB9A, TYR |
CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 2.381E-04 | 3.600E-02 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, HSD17B2, NOX4, RAB9A |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 2.827E-08 | 2.318E-06 | HSD17B1, ALOX5, HSD17B2, CYP1A1, CYP1B1 |
09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 6.052E-08 | 2.481E-06 | HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1 |
Unclassified | Unclassified | hsa01100 | Metabolic pathways | 9.432E-07 | 1.547E-05 | CYP2C9, GAA, HSD17B1, ALOX5, HSD17B2, CYP1A2, ALOX15, CYP1A1, AKR1B1, CYP2C19, TYR, XDH |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.033E-07 | 5.557E-06 | CYP2C9, CYP1A2, ALOX15, CYP2C19 |
09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 3.494E-07 | 7.162E-06 | CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP2C19 |
09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 4.578E-06 | 5.362E-05 | CYP2C9, ALOX5, ALOX15, CYP2C19 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 8.806E-06 | 9.027E-05 | CYP2C9, CYP1A2, CYP1A1, CYP1B1 |
09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 4.781E-05 | 3.768E-04 | CYP2C9, ALOX5, ALOX15, CYP2C19 |
09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 5.055E-05 | 3.768E-04 | CYP1A2, CYP1A1, CYP1B1 |
09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 6.825E-04 | 3.731E-03 | AR, FLT3, DAPK1, HIF1A, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 2.370E-04 | 1.495E-03 | FLT3, TP53, HIF1A |
09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 3.579E-06 | 4.892E-05 | CA12, CA2, CA7 |
09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 2.167E-04 | 1.481E-03 | CYP2C9, CYP1A2, CYP1A1 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 2.586E-04 | 1.515E-03 | CYP2C9, CYP1A2, CYP2C19 |
09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 1.931E-03 | 8.795E-03 | ABCC1, PIM1, CYP1B1, TP53 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.328E-03 | 6.804E-03 | GAA, AKR1B1 |
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.606E-03 | 7.746E-03 | POLB, APEX1 |
09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 3.139E-05 | 2.860E-04 | CYP1A2, XDH |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | TYR; |
M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | TYR; |
NA: NA | HIV infections | NA | AHR; |
L00-L99: Diseases of the skin and subcutaneous tissue | Melasma | L81.1 | TYR; |
C00-D49: Neoplasms | Multiple myeloma | C90 | AHR; |
C00-D49: Neoplasms | Melanoma | C43 | TYR; |