Plant Name: Swertia calycina
Taxonomic Information:
Plant ID: NPO22457
Plant Latin Name: Swertia calycina
Taxonomy Genus: Swertia
Taxonomy Family: Gentianaceae
Plant External Links:
NCBI TaxonomyDB:
166613
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| NR1H4; | |
| MAOA; | |
| UGT1A1; | |
| SLCO4C1; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | UGT1A1 | UDP-glucuronosyltransferase 1-1 | P22309 | CHEMBL1287617 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| SLC superfamily of solute carriers | SLCO4C1 | Solute carrier organic anion transporter family member 4C1 | Q6ZQN7 | CHEMBL2073690 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 7.764E-04 | 5.635E-01 | NR1H4 |
| MF | GO:0003824; catalytic activity | GO:0008131; primary amine oxidase activity | 1.552E-03 | 7.440E-01 | MAOA |
| MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.811E-03 | 7.440E-01 | NR1H4 |
| CC | GO:0044425; membrane part | GO:0005887; integral component of plasma membrane | 4.584E-02 | 1.000E+00 | SLCO4C1, UGT1A1 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 4.723E-02 | 1.000E+00 | SLCO4C1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.165E-04 | 3.146E-03 | UGT1A1, MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00340 | Histidine metabolism | 5.986E-03 | 2.610E-02 | MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00360 | Phenylalanine metabolism | 4.243E-03 | 2.610E-02 | MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00350 | Tyrosine metabolism | 8.720E-03 | 2.610E-02 | MAOA |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00053 | Ascorbate and aldarate metabolism | 6.732E-03 | 2.610E-02 | UGT1A1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 8.969E-03 | 2.610E-02 | UGT1A1 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 9.961E-03 | 2.610E-02 | MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00260 | Glycine, serine and threonine metabolism | 9.961E-03 | 2.610E-02 | MAOA |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00500 | Starch and sucrose metabolism | 1.392E-02 | 2.610E-02 | UGT1A1 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00860 | Porphyrin and chlorophyll metabolism | 1.046E-02 | 2.610E-02 | UGT1A1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
