Plant Name: Garcinia dulcis
Taxonomic Information:
Plant ID: NPO22337
Plant Latin Name: Garcinia dulcis
Taxonomy Genus: Garcinia
Taxonomy Family: Clusiaceae
Plant External Links:
NCBI TaxonomyDB:
231905
Plant-of-the-World-Online:
427931-1
Used in Medicines:
Country/Region:
Thailand; Indonesia; China; IndiaTraditional Medicine System:
Indian Folk; TCMGeographical Distribution:
Australia; Myanmar; Philippines; Indonesia; India; Trinidad and Tobago; China; Thailand
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ALOX12; ALOX15; IDH1; USP2; | |
| BACE1; | |
| NFKB1; RELA; | |
| EP300; | |
| MAPT; | |
| FASN; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| Bromodomain | EP300 | Histone acetyltransferase p300 | Q09472 | CHEMBL3784 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic | O75874 | CHEMBL2007625 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Transcription Factor | RELA | Nuclear factor NF-kappa-B p65 subunit | Q04206 | CHEMBL5533 |
| Transferase | FASN | Fatty acid synthase | P49327 | CHEMBL4158 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 4.468E-08 | 3.243E-04 | ALOX12, ALOX15, CYP19A1, CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 4.181E-07 | 9.105E-04 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 4.181E-07 | 9.105E-04 | ALOX12, ALOX15 |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 6.153E-07 | 1.031E-03 | ALOX12, ALOX15, CYP19A1, CYP2C19, CYP2C9, FASN, IDH1 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 1.254E-06 | 1.707E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 1.254E-06 | 1.707E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 1.408E-06 | 1.803E-03 | CYP19A1, CYP2C19, CYP2C9 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 3.325E-06 | 3.810E-03 | CYP19A1, CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0051122; hepoxilin biosynthetic process | 4.177E-06 | 4.134E-03 | ALOX12, ALOX15 |
| BP | GO:0008152; metabolic process | GO:2000630; positive regulation of miRNA metabolic process | 4.177E-06 | 4.134E-03 | NFKB1, RELA |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 6.262E-06 | 5.682E-03 | CYP2C19, CYP2C9 |
| BP | GO:0032501; multicellular organismal process | GO:0045075; regulation of interleukin-12 biosynthetic process | 8.764E-06 | 7.068E-03 | NFKB1, RELA |
| CC | GO:0032991; macromolecular complex | GO:0033256; I-kappaB/NF-kappaB complex | 8.764E-06 | 7.068E-03 | NFKB1, RELA |
| BP | GO:0009987; cellular process | GO:0071316; cellular response to nicotine | 1.168E-05 | 8.478E-03 | NFKB1, RELA |
| BP | GO:0032501; multicellular organismal process | GO:0032481; positive regulation of type I interferon production | 1.383E-05 | 9.712E-03 | EP300, NFKB1, RELA |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 5.861E-08 | 5.158E-06 | CYP2C9, ALOX15, ALOX12, CYP2C19 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 6.409E-07 | 2.277E-05 | CYP2C9, ALOX15, ALOX12, CYP2C19 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 4.244E-06 | 9.337E-05 | CYP2C9, FASN, IDH1, ALOX15, ALOX12, CYP2C19, CYP19A1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 7.763E-07 | 2.277E-05 | CYP2C9, ALOX15, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 2.359E-05 | 4.152E-04 | EP300, RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 3.654E-05 | 5.360E-04 | EP300, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 1.033E-04 | 1.299E-03 | EP300, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05164 | Influenza A | 1.766E-04 | 1.815E-03 | EP300, RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 2.578E-04 | 1.905E-03 | EP300, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05152 | Tuberculosis | 1.857E-04 | 1.815E-03 | EP300, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05169 | Epstein-Barr virus infection | 2.694E-04 | 1.905E-03 | EP300, RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 2.814E-04 | 1.905E-03 | EP300, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05168 | Herpes simplex infection | 2.080E-04 | 1.831E-03 | EP300, RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 5.330E-04 | 2.825E-03 | MAPT, RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 5.515E-04 | 2.825E-03 | EP300, RELA, NFKB1 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05030 | Cocaine addiction | 4.508E-04 | 2.825E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 6.100E-04 | 2.825E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 5.680E-04 | 2.825E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 8.172E-04 | 2.835E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 6.100E-04 | 2.825E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 7.927E-04 | 2.835E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 8.672E-04 | 2.835E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 7.686E-04 | 2.835E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 9.716E-04 | 2.835E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 7.927E-04 | 2.835E-03 | RELA, NFKB1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 8.928E-04 | 2.835E-03 | CYP2C9, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 9.986E-04 | 2.835E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 9.986E-04 | 2.835E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.914E-03 | 4.212E-03 | EP300, NFKB1, RELA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 9.187E-04 | 2.835E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 9.986E-04 | 2.835E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04622 | RIG-I-like receptor signaling pathway | 9.187E-04 | 2.835E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.899E-03 | 4.212E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 1.382E-03 | 3.475E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 1.648E-03 | 3.920E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05146 | Amoebiasis | 1.862E-03 | 4.212E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 1.054E-03 | 2.898E-03 | RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04064 | NF-kappa B signaling pathway | 1.614E-03 | 3.920E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.258E-03 | 3.354E-03 | CYP2C9, CYP2C19 |
| 09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 2.012E-03 | 4.216E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 2.089E-03 | 4.276E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05132 | Salmonella infection | 1.382E-03 | 3.475E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05142 | Chagas disease (American trypanosomiasis) | 2.012E-03 | 4.216E-03 | RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 2.247E-03 | 4.395E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 2.207E-03 | 4.395E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 2.580E-03 | 4.889E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 2.667E-03 | 4.889E-03 | RELA, NFKB1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 3.608E-03 | 6.105E-03 | RELA, NFKB1 |
| 09150 Organismal Systems | 09158 Development | hsa04380 | Osteoclast differentiation | 3.215E-03 | 5.743E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 4.182E-03 | 6.944E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 3.409E-03 | 5.882E-03 | RELA, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 2.667E-03 | 4.889E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 3.263E-03 | 5.743E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 5.148E-03 | 8.390E-03 | BACE1, MAPT |
| 09150 Organismal Systems | 09151 Immune system | hsa04062 | Chemokine signaling pathway | 6.338E-03 | 9.960E-03 | RELA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 5.886E-03 | 9.418E-03 | RELA, NFKB1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
