CMAUP Plant Collective Molecular Activities

Plant Name: Sechium edule

Taxonomic Information:

Plant ID: NPO22318
Plant Latin Name: Sechium edule
Taxonomy Genus: Sechium
Taxonomy Family: Cucurbitaceae

Plant External Links:

NCBI TaxonomyDB: 184140
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Madagascar; Angola; South Africa; Indonesia; Zimbabwe; Swaziland

Traditional Medicine System:

Geographical Distribution:

Madagascar; Angola; South Africa; Indonesia; Zimbabwe; Swaziland

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	EIF4A1;
Transcription Factor	RELA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	EIF4A1	Eukaryotic initiation factor 4A-I	P60842	CHEMBL2052028
Transcription Factor	RELA	Nuclear factor NF-kappa-B p65 subunit	Q04206	CHEMBL5533

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0033590; response to cobalamin	3.106E-04	1.000E+00	RELA
BP	GO:0008152; metabolic process	GO:2000630; positive regulation of miRNA metabolic process	5.177E-04	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:0071316; cellular response to nicotine	8.282E-04	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:0071354; cellular response to interleukin-6	1.553E-03	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0010224; response to UV-B	1.863E-03	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0035994; response to muscle stretch	1.966E-03	1.000E+00	RELA
BP	GO:0008152; metabolic process	GO:0031293; membrane protein intracellular domain proteolysis	1.966E-03	1.000E+00	RELA
BP	GO:0008152; metabolic process	GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter	2.277E-03	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:1901522; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	2.897E-03	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0046627; negative regulation of insulin receptor signaling pathway	3.104E-03	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0043278; response to morphine	3.311E-03	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:1901224; positive regulation of NIK/NF-kappaB signaling	4.344E-03	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	6.306E-03	1.000E+00	RELA
BP	GO:0032501; multicellular organismal process	GO:0032481; positive regulation of type I interferon production	7.441E-03	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0051591; response to cAMP	9.916E-03	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:2001237; negative regulation of extrinsic apoptotic signaling pathway	1.064E-02	1.000E+00	RELA
BP	GO:0032501; multicellular organismal process	GO:0001889; liver development	1.084E-02	1.000E+00	RELA
BP	GO:0009987; cellular process	GO:0043620; regulation of DNA-templated transcription in response to stress	1.218E-02	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0071222; cellular response to lipopolysaccharide	1.228E-02	1.000E+00	RELA
BP	GO:0002376; immune system process	GO:0002223; stimulatory C-type lectin receptor signaling pathway	1.270E-02	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	1.434E-02	1.000E+00	RELA
BP	GO:0065007; biological regulation	GO:0051092; positive regulation of NF-kappaB transcription factor activity	1.444E-02	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0071375; cellular response to peptide hormone stimulus	1.670E-02	1.000E+00	RELA
BP	GO:0032502; developmental process	GO:0007568; aging	2.378E-02	1.000E+00	RELA
BP	GO:0050896; response to stimulus	GO:0050727; regulation of inflammatory response	3.977E-02	1.000E+00	RELA
BP	GO:0032502; developmental process	GO:0009887; animal organ morphogenesis	4.565E-02	1.000E+00	RELA
CC	GO:0032991; macromolecular complex	GO:0033256; I-kappaB/NF-kappaB complex	7.247E-04	1.000E+00	RELA
CC	Unclassified;	GO:0043234; protein complex	2.693E-02	1.000E+00	EIF4A1, RELA
CC	GO:0044464; cell part	GO:0005737; cytoplasm	4.631E-02	1.000E+00	EIF4A1, RELA
MF	GO:0005488; binding	GO:0051059; NF-kappaB binding	2.897E-03	1.000E+00	RELA
MF	GO:0140110; transcription regulator activity	GO:0001205; transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding	3.001E-03	1.000E+00	RELA
MF	GO:0005488; binding	GO:0042805; actinin binding	4.241E-03	1.000E+00	RELA
MF	GO:0005488; binding	GO:0070491; repressing transcription factor binding	6.203E-03	1.000E+00	RELA
MF	GO:0005488; binding	GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding	7.441E-03	1.000E+00	RELA
MF	GO:0005488; binding	GO:0042826; histone deacetylase binding	1.115E-02	1.000E+00	RELA
MF	GO:0005488; binding	GO:0001046; core promoter sequence-specific DNA binding	1.156E-02	1.000E+00	RELA
MF	GO:0140110; transcription regulator activity	GO:0001077; transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	2.807E-02	1.000E+00	RELA
MF	GO:0005488; binding	GO:0000978; RNA polymerase II proximal promoter sequence-specific DNA binding	4.038E-02	1.000E+00	RELA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	5.692E-03	1.944E-02	RELA
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6.789E-03	1.944E-02	RELA
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	6.390E-03	1.944E-02	RELA
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	7.187E-03	1.944E-02	RELA
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	7.287E-03	1.944E-02	RELA
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	7.287E-03	1.944E-02	RELA
09150 Organismal Systems	09151 Immune system	hsa04622	RIG-I-like receptor signaling pathway	6.988E-03	1.944E-02	RELA
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	1.177E-02	1.944E-02	RELA
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	1.196E-02	1.944E-02	RELA
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.196E-02	1.944E-02	RELA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases