CMAUP Plant Collective Molecular Activities

Plant Name: Digitalis lanata

Taxonomic Information:

Plant ID: NPO22245
Plant Latin Name: Digitalis lanata
Taxonomy Genus: Digitalis
Taxonomy Family: Plantaginaceae

Plant External Links:

NCBI TaxonomyDB: 49450
Plant-of-the-World-Online: 802028-1

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

Indian Folk; TCM

Medicinal Functions:

Cardiac; Stimulant; Tonic

Geographical Distribution:

Turkey; Ukraine; Romania; Albania; India; Austria; China; Greece; Hungary; Bulgaria

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ATP1A1; ATP12A;
Enzyme_unclassified	TDP1; RECQL; GFER;
Protein Kinase	PIM1;
Nuclear hormone receptor subfamily 1 group F	RORC;
Transcription Factor	STAT3; TP53;
SLC superfamily of solute carriers	SLCO4C1; SLCO1B1; SLCO1B3;
Unclassified	KLF5; MAPT; GMNN; PAX8; RAB9A; NPC1; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Hydrolase	ATP1A1	Sodium/potassium-transporting ATPase alpha-1 chain	P05023	CHEMBL1807
Hydrolase	ATP12A	Potassium-transporting ATPase alpha chain 2	P54707	CHEMBL2933
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
SLC superfamily of solute carriers	SLCO4C1	Solute carrier organic anion transporter family member 4C1	Q6ZQN7	CHEMBL2073690
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
Transcription Factor	STAT3	Signal transducer and activator of transcription 3	P40763	CHEMBL4026
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	KLF5	Kruppel-like factor 5	Q13887	CHEMBL1293249
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	GMNN	Geminin	O75496	CHEMBL1293278
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	2.209E-06	2.405E-02	SLCO1B1, SLCO1B3, SLCO4C1
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.409E-06	2.405E-02	ATP12A, ATP1A1, SLCO1B1, SLCO1B3, SLCO4C1
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	3.565E-06	2.588E-02	SLCO1B1, SLCO1B3, SLCO4C1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	1.950E-04	9.670E-03	STAT3, RAB9A, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.724E-04	9.670E-03	PAX8, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	STAT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	STAT3; ATP1A1; TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	STAT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Hyperhidrosis	R61	ATP1A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
NA: NA	Arrhythmias	NA	ATP1A1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ATP1A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ATP1A1;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ATP1A1;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	ATP1A1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ATP1A1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
C00-D49: Neoplasms	Multiple myeloma	C90	STAT3;
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	ATP1A1;
NA: NA	Congestive cardiac insufficiency	NA	ATP1A1;
C00-D49: Neoplasms	Solid tumours	C00-D48	STAT3; TP53;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases